Sürdürülebilir Kalkınma Amaçları
Yayınlar
- BildiriAçık Erişim2015Scopus SJRQ1Antiproliferative effects of Evernic acid on A549 and healthy human cells: An in vitro study
Kizil, Hamit Emre; Agar, Guleray; Anar, Mustafa
AtıfWoS3OpenAlex4
İncele - BildiriAçık Erişim2015Scopus SJRQ1Determination of cytotoxic and proliferative effects of 2-amino-5-nitrobenzonitrile on AGS cancer cell line
Anar, Mustafa; Kizil, Hamit Emre; Agar, Guleray
- MakaleYalnız künye2015Scopus SJRQ3Determination of antigenotoxic effects of four lichen species by using human lymphocytes
Anar, Mustafa; Asian, Ali; Ceker, Selcuk; Kizil, Hamit Emre; Alpsoy, Lokman; Agar, Guleray
In this study, the geno-toxic and antigeno-toxic properties of the total extracts of four lichen species were investigated by using human lymphocytes. We obtained total extracts from R farinacea, X. parietina, U. articulataand U. filipendula lichen species. The results of our studies showed that 5 μM concentrations of AFB1 changed the frequencies of micronucleus (MN) and malondialdehyde (MDA) levels, as well as superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx) activities. When 5,10 and 20 μg/ml concentrations of total extract were added to AFB1, the frequencies of MN and MDA levels were decreased, and SOD, GSH and GPx levels were increased. Consequently, our findings show that four lichen total extracts have strong antigenotoxic properties against aflatoxin Bi.
AtıfScopus3
İncele - BildiriAçık Erişim2014Scopus SJRQ1The determination of antioxidative effect and anticancer potential of vulpinic acid
Anar, Mustafa; Kizil, Hamit Emre; Agar, Guleray
AtıfOpenAlex1İncele - BildiriAçık Erişim2014Scopus SJRQ1Cytotoxic and antiproliferative effects of evernic acid on HeLa cell lines: A candidate anticancer drug
Kizil, Hamit Emre; Agar, Guleray; Anar, Mustafa
AtıfWoS6OpenAlex10İncele - MakaleYalnız künye2012Scopus SJRQ4Investigation of anti-oxidative and anti-genotoxic effects of Origanum vulgare L. essential oil on human lymphocytes in vitro
Ceker, Selcuk; Agar, Guleray; Nardemir, Gokce; Anar, Mustafa; Kizil, Hamit Emre; Alpsoy, Lokman
Origanum vulgare L. (Lamiaceae) is a flavoring herb widely using around the world. Some preparations and extracts from O. vulgare have been used in Turkish traditional medicine to treat several ailments including digestive disorders and menstrual problems. This study is designed to examine the chemical composition and in vitro antigenotoxic and antioxidant activity of the essential oil of O. vulgare (OVE) from Turkey. The essential oil of O. vulgare was analized by using GC. OVEs that were investigated antagonistic effects against oxidative stress and the genotoxic effects of aflatoksin B1 (AFB1). Anti-genotoxic activity was evaluated by sister chromatid exchanges (SCEs) and micronucleus (MN) tests. In additional to investigating protective role of OVEs against the oxidative stress of AFB1 in vitro, oxidative status was assessed on erythrocytes by measuring following oxidative stress markers like; super oxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA).The total of the 25 identified components are accounted for 96.03 % (GC). Major components of the oil were β-caryophyllene (20.40%), and caryophyllene oxide (34.44%). In the SCE and MN tests, it was observed that OVEs suppressed the mutagenic effects of AFB1. OVEs were observed to modulate the adverse effects of AFB1. The results of this experiment clearly reveal that OVEs have strong anti-oxidative and anti-genotoxic effect. These anti-genotoxic effects of O. vulgare essential oils are probably related to its action on the enzymatic activation system. Anti-oxidative and anti-genotoxic effect may be role of these compounds (β-caryophyllene and caryophyllene oxide).
AtıfScopus14WoS16OpenAlex12İncele