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- Kitap BölümüAçık Erişim2023Enigmatic secondary metabolites: Microbial melanins and their applications
Narang, Urja; Kurian, Noble K; Bayram, Sinan
Melanin is a biomacromolecule found in all kingdoms of life that ranges from dark brown to black pigment. Eumelanin, allomelanin, neuromelanin, and pheomelanin are all types of melanin. They possess a wide range of bioactive properties, including antioxidant, radioprotective, antimicrobial, antiviral, antiinflammatory, antiproliferative, and photoprotective properties. Melanin has anticancer and antimicrobial properties that make it useful in pharmacology and medicine. In addition, it has applications in cosmetics; to mimic the natural process of these compounds in the skin, many manufacturers have embraced the use of melanin in sunscreens. Furthermore, due to the absorption of ultraviolet rays, mixed electronic-ionic conductivity, and hydration state-dependent electrical properties of melanin, it is used in organic electronics such as solar cells, batteries, and biosensors. This review examines the various functions and applications of this biological pigment, as well as its distinct physicochemical, chemical, bioactive, and anticorrosive properties.
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İncele - MakaleAçık Erişim2023Scopus SJRQ2Determination of toxicity and radioprotective properties of bacterial and fungal eumelanin pigments
Bayram, Sinan; Aygün, Bünyamin; Karadayi, Mehmet; Alaylar, Burak; Güllüce, Medine; Karabulut, Abdulhalik
Purpose: Determination of the protective property of melanin, an organic polymer class consisting of phenolic and/or indolic compounds isolated from bacteria and fungi, against fast neutron radiation. To show that these melanin samples, which also have antioxidant and metal chelating properties, can be used as an active ingredient for a drug to be developed against neutrons used in nuclear research and medicine. Materials and methods: Bacterial and fungal media were prepared, and melanin pigments were produced and isolated. For molecular characterization of pigments, bacterial genomic DNA extraction, 16S rDNA gene amplification processes, and fungal genomic DNA extraction, ITS1, and ITS4 Gene Regions amplification were performed. The DEL assay was implemented to determine the genotoxicity properties of bacterial and fungal melanin pigments. Samples were prepared in a pad measuring 10 ml volume (60 × 15 mm) at a concentration of 0.2–1 microgram in 1% agarose gel for radiation-absorbed dose measurements. Absorption measurements were made using 241Am-Be fast neutron source and Canberra brand NP series BF3 gaseous detector to determine the neutron radiation absorption capacity of all samples. The results obtained to determine the absorption degrees of melanin samples were compared with paraffin and normal concrete, which are widely used in neutron radiation shielding studies. Results: Melanin pigments were obtained using different bacteria and fungi strains. Afterwards, the fast neutron radiation absorption capacity of these purified pigments were determined. Compared to reference samples, these pigments were found to have slightly lower radiation absorbing ability. In addition to these experiments, cytotoxicity tests were carried out using the Yeast DEL assay technique to evaluate the potential for use of these organic pigments in fields such as medicine and pharmacology. According to the results obtained from the tests, it was determined that these melanin samples did not have any toxic effects. Conclusion: It was determined that these melanin samples have the potential to be used as a radioprotective drug active substance to protect the tissues and cells of people exposed to neutron radiation after a nuclear accident or nuclear war. Giving a drug that will be developed by using these active ingredients before or after people are exposed to a radiation environment can provide great benefits.
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İncele - MakaleAçık Erişim2023Scopus SJRQ1Exploring the Charge Transport of a Natural Eumelanin for Sustainable Technologies
Paulin, João V.; Bayram, Sinan; Graeff, Carlos F. O.; Bufon, Carlos C. B.
Eumelanin, the main quinone-based biomaterial of the melanin family of compounds, is emerging as a model for medical and sustainable electronic interfaces due to its biocompatibility, biodegradability, and transducing abilities. The study utilizes current-voltage measurements and impedance/dielectric spectroscopy under a controlled hydration atmosphere to investigate the charge transport of eumelanin produced from the S. parvus BSB49 strain. We show no differences in the electrical response in highly hydrated conditions compared to the standard synthetic eumelanin. Hence, our findings provide the groundwork to assess the potential use of this natural eumelanin in sustainable organic (bio)electronic applications.
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