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- MakaleAçık Erişim2024Scopus SJRQ2Antioxidant activity and phenolic composition of propolis from Marmara region, Turkey
Can, Zehra; Kara, Yakup; Kolayli, Sevgi; Çakmak, Ibrahim
This study investigated various properties of raw propolis samples from Marmara region of Turkey. Total phenolic content (TPF), total flavonoid (TFC) values, condensed tannin content (CTC) and phenolic profiles of ethanolic extracts (70%) were analyzed. Antioxidant activities were tested using the Ferric (III) reduction/antioxidant capacity (FRAP) and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging methods. Phenolic profiles of the samples were analyzed using high performance liquid chromatography (RP-HPLC-UV) method. TPC, TFC and CTC values in the samples ranged from 52.9 to 203.5 mg GAE/g, 13.6 to 43.9 mg QUE/g, and 2.0 and 2.9 mg CTE/g, respectively. Caffeic acid phenyl ester (CAPE), chrysin, pinocembrin, rutin, and t-cinnamic acid were detected as the common phenolic components in all samples. In conclusion, Marmara region propolis is a rich source of bioactive compounds, especially flavonoids with antioxidant properties.
AtıfScopus14WoS12
İncele - MakaleAçık Erişim2024Scopus SJRQ1Determination of phenolic content and bioactive characterization of Anatolian propolis
Can, Zehra; Birinci, Ceren; Kara, Yakup; Esertaş, Ülkü Zeynep Üreyen; Kolaylı, Sevgi
In this study, propolis referred to as of Türkiye Anatolian propolis was utilized. This work was aim to prepare a 70% ethanolic extract of propolis and subsequently determine certain biochemical parameters, total phenolic content (TPC), total flavonoid content (TFC), phenolic and flavonoid composition, inhibitory effects on certain enzymes [acetylcholinesterase (AChE), urease, and alpha-amylase], along with assessments of antiviral activity against Vero cells, lung cancer cells (A549), and breast cancer cells (MDA-MB-231). The richness of phenolic content in Anatolian propolis clearly indicates a high inhibitory effect on these enzymes. Additionally, it was observed to exert significant effects on cancer cells and demonstrated effective antiviral activity. It can be contemplated that the Anatolian propolis might serve as a potential source for novel drugs, and the isolation of its compounds could offer opportunities for utilization in traditional medicine.
AtıfScopus9WoS10OpenAlex11İncele - MakaleYalnız künye2019Scopus SJRQ4Appropriate maceration duration for the extraction of propolis
Ecem-Bayram, Nesrin; Gercek, Ynsuf Can
The importance of the use of natural products as nutritional supplements in order to increase the quality of life and prevent diseases has increased in recent years. Among these products, propolis produced by honey bees is collected from plants and has a very complex structure in terms of chemical content. Propolis and its extracts have been used by humans for centuries because of its various bioactive properties. Although different methods can be used in the extraction stage, the most commonly used technique is extraction by maceration. However, there is no standard time period for extraction of propolis by maceration. We aimed to determine the changes in the concentrations of flavonoid group compounds pinocembrin, chrysin, tectochrysin, pi-nostrobin chalcone, gengwanin, naringenin and galangin from propolis samples exposed to seven different periods (1, 2, 5 10, 15, 20, 30 days) of maceration using GC-MS. The flavonoids pinocembrin, chrysin, tectochrysin, and naringenin reached their maximum concentrations at the end of 15 days of maceration and a decrease in their concentrations was observed after this period. The concentrations of other flavonoids did not show a steady increase or decrease with different maceration times. As a result, it can be said that the appropriate duration of maceration to extract the flavonoids responsible for propolis' numerous activities varies depending on the origin of the propolis and the nature of the compounds to be extracted.
AtıfScopus9İncele - MakaleAçık Erişim2018Scopus SJRQ2Chemical characterization of 64 propolis samples from hakkari, Turkey
Bayram, Nesrin Ecem; Sorkun, Kadriye; Öz, Gül Cevahir; Salih, Bekir; Topçu, Gülaçtı
Propolis is a resinous substance produced by honey bees from various plants they visit. Sixty-four propolis samples were collected from different localities of four districts (Merkez, Yüksekova, Şemdinli, and Çukurca) in Hakkari territory. Ethanol extracts of the propolis samples were prepared, and their chemical contents were determined by gas chromatography–mass spectroscopy (GC–MS). Flavonoids were generally found in a high concentration in Şemdinli samples of Turkey. Twenty-seven coumarins were identified in the 28 propolis samples among studied 64 ones. Except suberosin, the coumarins were never reported before in any propolis sample with Turkish origin. The propolis samples belonging to Yüksekova were found to be richer in coumarins than the others, and the most richest one among the Yüksekova apiaries, was found to be Akocak sample (Y2) with 41.99% total yield, followed by Akçalı sample (Y5) (30.86%). This is a first comprehensive and original report about the chemical profile of propolis samples from Hakkari. The propolis samples from Hakkari exhibited a chemical content rich in flavonoids including coumarins and furocoumarins.
AtıfScopus16WoS14OpenAlex23İncele