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- MakaleAçık Erişim2025Scopus SJRQ3The Effect of Cannabidiol on Myokine, Cerebral and Cardiac Response in Rats with Sepsis Induced by Cecal Ligation and Punture Method
Erkiliç, T. Orkun; Bayraktar, B.
Background: The aim of this study was to investigate the effects of Cannabidiol on myokine (Irisin), cerebral (BDNF) and cardiac (cTnI) responses in sepsis-induced rats by Cecal Ligation Perforation (CLP) method. Methods: In this study, 40 adult male Wistar albino rats, aged between 8-10 weeks, were used. 5 groups were created, with 8 rats in each group: Control (C), Sham (S), CLP, CLP+CBD 2.5 mg/kg, CLP+CBD 5 mg/kg group. Rats in groups C and Sham were sacrificed at the end of the 10th hour and intracardiac blood was taken immediately afterwards. In groups CLP, CLP+2.5 mg/kg, CLP+5 mg/kg, intra-abdominal sepsis was induced and at the end of the 10th hour after sepsis occurred with CLP application, rats were sacrificed and intracardiac blood was taken immediately afterwards. İrisin, BDNF and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, mean serum irisin, BDNF and levels were determined to be at the lowest level in the CLP group, while cTnI levels were at the highest level (p<0.01). In CLP groups, serum irisin and BDNF levels increased due to CBD addition and the most significant decrease in cTnI levels occurred in 5 mg/kg CBD groups. As a result, it was concluded that CLP may be safe and beneficial when administered at a dose of 5 mg/kg in sepsis-induced rats.
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İncele - MakaleAçık Erişim2021Scopus SJRQ4Investigation of the relationship of asprosin and cardiac troponin response with some physiological and biochemical parameters in Anatolian native horse
Bayraktar, Bülent; Tekce, Emre
Summary: Asprosin is a recently discovered glucogenic hormone released from starvation-induced white adipose tissue and amongst others it protects against hyperinsulinism associated with metabolic syndrome. The aim of this study was to examine the effect of age, gender and season on metabolic (asprosin) and cardiovascular (cardiac troponin, I (cTnI), CK, CK-MB) function markers and their relationship with some biochemical parameters in Anatolian native horse breed. This study was carried out between February–August 2020. A total of 40 horses was used for this purpose, including 20 mares and 20 stallions in the age range of 1–6, 7–12. Serum asprosin level, for the winter season in stallions and mares aged 1–6 and 7–12 years respectively 8.9, 8.36; 14.08, 13.58ng/ml were as determined. In addition, for the summer season respectively 17.98, 18.68; 22.22, 21.32ng/ml were detected and no difference between the groups (P>0.05). On the other hand, serum cTnI levels for the winter season in stallions and mares aged 1–6 and 7–12 years respectively 0.014, 0.018; 0.016, 0.02ng/ml were as determined. In addition, for the summer season respectively 0.012, 0.016; 0.014, 0.018ng/ml were detected. It was shown that the serum biochemical parameters and levels of cTnI levels in the domestic horse breed the horses belonging to the Anatolian varied depending on age, gender, and season (p < 0.05) but the effect of hormone levels serum asprosin wasn’t found statistically significant (p>0.05).Our results showed that cTnI could be a useful parameter in the examination of the cardiovascular system status of horses.
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