Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Bayraktar, Bülent(4)
- Tekce, Emre(2)
- Aksakal, Vecihi(1)
- Battal, Fetullah(1)
- Bayraktar, Bulent(1)
- Bayraktar, Fatma Gülten(1)
- Bayraktar, Sevil(1)
- Bi̇lgi̇n, Öznur(1)
- Bozok, Ümmü Gülşen(1)
- Can, Özgür Devrim(1)
- Demi̇r Özkay, Ümide(1)
- Eser, Gizem(1)
- Gül, Mehmet(1)
- Kandemi̇r, Ümmühan(1)
- Karaalp, Musa(1)
- Kaya, Hacer(1)
- Okur, Süheyb(1)
- Takma, Çiğdem(1)
- Tosun Köse, Fatma(1)
- Turan Yücel, Nazlı(1)
- Turunc, Eylul(1)
- Yazici, Cevşen(1)
- Özcan, Gülbahar Böyük(1)
- Özek, Temel(1)
- Özen, Doğukan(1)
- Üçel, Umut İrfan(1)
- İşcan, Gökalp(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ2Acute Music-Frequency Exposure Modulates Salivary Stress and Neurotrophic Markers in Young Adults: A Randomized Controlled Trial
Bozok, Ümmü Gülşen; Özcan, Gülbahar Böyük; Bayraktar, Bülent; Özen, Doğukan
Background: The exam period is a period full of intense stress and anxiety that deeply affects cognitive and physiological responses for university students. Listening to music has the potential to protect cellular health and alleviate the negative effects of stress by affecting individuals' mood, and cognitive functions. This study aimed to investigate the differential effects of 528 and 432 Hz music frequencies on salivary BDNF, CREB, and GRP78 levels in young adults, along with their association with cognitive performance under exam-related stress. Methods: A total of 162 healthy university students were randomly assigned to three groups: no music (control), 528 Hz instrumental music, and 432 Hz instrumental music. Participants listened to music for 20 min, after which saliva samples were collected and analyzed for brain-derived neurotrophic factor (BDNF), glucose-regulated protein 78 (GRP78) and cyclic AMP response element-binding protein (CREB) levels using ELISA. Cognitive performance was assessed using the Stroop word-color test administered by medical doctor. Results: Exposure to 528 Hz music significantly increased salivary BDNF (3.84 [2.76–4.13]) and CREB levels (1.5 [1.38–1.59]) compared to control (p < 0.05), whereas GRP78 levels were elevated in the 432 Hz group (0.51 [0.47–0.58]) (p < 0.05). No significant differences were observed between groups in Stroop test performance. Conclusion: These findings suggest that specific music frequencies elicit distinct biological responses under exam-related stress, even in the absence of immediate cognitive performance differences. Salivary neurotrophic and stress-related biomarkers may offer valuable non-invasive insights into music's neuromodulatory effects. Trial Registration: ClinicalTrials.gov identifier: AMU-EC-8522.
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İncele - MakaleAçık Erişim2026Scopus SJRQ1Cognitive improvement and hippocampal BDNF/GFAP alterations by Schinus molle essential oil in a rat model of scopolamine-induced amnesia
Üçel, Umut İrfan; Kandemi̇r, Ümmühan; Yazici, Cevşen; Bi̇lgi̇n, Öznur; Turan Yücel, Nazlı; Özek, Temel; Demi̇r Özkay, Ümide; İşcan, Gökalp; Can, Özgür Devrim
Ethnopharmacological relevanceSchinus molle L. (Anacardiaceae) has been traditionally used for conditions related to the nervous system and emotional well-being, often through aromatic preparations. However, its cognition-specific effects have not yet been investigated.Aim of the studyTo assess the cognitive effects of the fruit-derived essential oil of Schinus molle L. (SMEO), administered via oral and inhalation routes, in a rat model of scopolamine-induced amnesia.Materials and methodsSMEO was obtained by hydrodistillation and characterised by GC–MS/GC–FID. Amnesic rats received SMEO for 14 days by inhalation (1% or 3%) or oral gavage (100 or 200 mg/kg). Cognition was assessed by Morris water maze (MWM), passive avoidance (PA), and novel object recognition (NOR) tests; locomotion was measured by activity-meter. Hippocampal BDNF and GFAP immunoreactivity were assessed by immunohistochemistry.ResultsSMEO was dominated by α-phellandrene (48.7%). Scopolamine impaired cognition, whereas SMEO attenuated deficits with efficacy comparable to piracetam. Key behavioural and immunohistochemical findings (main omnibus statistical effects) were as follows: In the MWM, treatment and time effects on escape latency were significant (both p < 0.001), and probe performance improved (p < 0.001). PA retention was restored (p < 0.001) and the NOR index improved (p < 0.001), without locomotor changes (all p > 0.05). Scopolamine reduced hippocampal BDNF immunoreactivity in CA1 and DG (p < 0.01) and CA3 (p < 0.001), which was restored by SMEO via both routes. GFAP immunoreactivity was reduced in CA1/CA3/DG (all p < 0.001) and was rescued selectively after inhalation.ConclusionsThese findings provide preclinical evidence consistent with an ethnopharmacological rationale for SMEO and support further translational work to clarify its relevance beyond this experimental paradigm.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2The Relationship Between Metacognitive Beliefs and Salivary Cortisol, BDNF, and NDNF Levels: A Cross-Sectional Study
Okur, Süheyb; Bayraktar, Bülent; Tosun Köse, Fatma
Purpose: The main objective of this study is to non-invasively investigate the relationship between metacognitive beliefs and cortisol, the primary stress output of the hypothalamic-pituitary-adrenal (HPA) axis, as well as neurotrophic factors associated with neuroplasticity brain-derived neurotrophic factor and neuron-derived neurotrophic factor (BDNF and NDNF). Within this framework, the hypotheses that negative metacognitions would be associated with increased cortisol and decreased BDNF levels, and that cortisol might play a mediating role in this relationship, were tested. Method: The study was designed in a cross-sectional model with 60 university students. Participants' metacognitive beliefs were measured using the Metacognitions Questionnaire-30 (MCQ-30). Salivary cortisol, BDNF, and NDNF levels were analyzed using the ELISA method. Pearson correlation and hierarchical multiple regression analyses were used for data analysis. Finding: The results showed a significant positive relationship between the total metacognition score and cortisol (r = 0.589, p < 0.01) and a strong negative relationship between cortisol and BDNF (r = −0.662, p < 0.01). Hierarchical regression analysis supported a partial mediation model, indicating that dysfunctional metacognitive beliefs have both a significant direct negative association with BDNF and an indirect association mediated by cortisol. In the final model, both metacognition (β = –0.298, p < 0.05) and cortisol (β = –0.281, p < 0.05) were significant factors associated with lower BDNF levels. NDNF showed a positive relationship with BDNF (r = 0.571) but not with other variables. Conclusion: These findings point to a psychobiological model where dysfunctional metacognitive beliefs are linked to suppressed neuroprotective mechanisms like BDNF, both directly and indirectly through HPA axis activation. The results shed light on the potential neurobiological mechanisms underlying the effectiveness of metacognitive therapies.
AtıfScopus4WoS4OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1The relationship between emotional intelligence levels, stress management skills and hormonal and cerebral responses in university students
Bayraktar, Bülent; Battal, Fetullah
Background: Emotional intelligence is a person’s ability, capacity and ability to understand, use, understand, manage, anticipate, manage and direct the emotions of oneself or others. Students with high levels of emotional intelligence express themselves better, are more resistant to stress in their lives, and are individuals who can direct their emotions. Leaders with strong emotional intelligence will create synergy for all employees. Therefore, emotional intelligence and stress management skills are important issues in the field of leadership and organizational behavior. At the same time, emotional intelligence and stress management skills interact with hormones. This study aims to examine the emotional intelligence levels and hormone (apelin, cortisol) and cerebral (Brain-derived neurotrophic factor (BDNF)) response of 4th-year students of the faculty of health sciences at the university, who are potential managers of the future in terms of some variables. Methods: The research was conducted using the cross-sectional data method with 167 university students aged 18–24 who were reported to be clinically healthy in Türkiye. Apelin, cortisol hormone and BDNF levels in the participants’ saliva samples were analyzed using the ELISA technique. The relationship between emotional intelligence level and total scores from the stress coping scale and salivary apelin, cortisol and BDNF levels were evaluated. Results: In the study, it was determined that the average level of apelin hormone in saliva was “2.36 ± 0.076)’’ ng/mL in girls and “2.57 ± 0.071’’ ng/mL in boys. In girls, the BDNF level was “3.19 ± 0.97’’ and the cortisol level was “2.04 ± 0.72’’. BDNF level in boys is “3.41 ± 0.94’’and cortisol level is “1.92 ± 0.59’’. There is a significant difference between the participants’ allowances (income levels) and the average levels of salivary apelin hormone, BDNF and emotional intelligence scale (p < 0.01). A positive, strong and statistically significant relationship was found between the participants’ emotional intelligence level and stress management skills and apelin and BDNF levels, and a negative, strong and statistically significant relationship was found between salivary cortisol levels (p˂0.01). Conclusions: High emotional intelligence and stress management skills are an important element of strategic importance for a successful management and professional success process in individuals who will work in fields that need people such as health, marketing, law, consultancy, medicine, teaching and the service sector. Our study determined that as university students’ emotional intelligence levels strengthened, the participants’ stress management skills, salivary apelin, and BDNF levels increased, and cortisol hormone levels decreased. As a result, monitoring and examining apelin, BDNF, cortisol hormones can be useful parameters in evaluating the interaction between individuals’ emotional intelligence level and stress management skills and hormone response.
AtıfScopus3WoS3OpenAlex5İncele - MakaleAçık Erişim2020Scopus SJRQ3The impact of dietary tarragon (Artemisia dracunculus) on serum apelin, brain-derived neurotrophic factor, cardiac troponin concentrations and histopathology of liver tissue in laying hens housed at different stocking densities
Bayraktar, Bulent; Tekce, Emre; Kaya, Hacer; Karaalp, Musa; Turunc, Eylul
Due to its association with several other stress factors (poultry house gases, inadequate ventilation, heat, cold and poor hygiene), the high stocking density is a major stress factor that adversely affects the health and performance of poultry and the quality of the poultry products. Therefore, this experimental study was aimed at analysing the impact of different doses of dietary tarragon (Artemisia dracunculus) on the serum apelin, plasma brain-derived neurotrophic factor (p-BDNF), and cardiac troponin I (cTnI) concentrations, and the correlation between these indicators in laying hens housed at different stocking densities. The aim of this study is to investigate the effects of adding tarragon in different ratios to laying hen rations in the 2ndovulation period on the cTnI, apelin, and BDNF hormone concentrations and the liver histopathology. The experiment was carried out over a period of eight weeks, with 192 Lohman Brown commercial hybrids at 50 weeks of age. Eight groups (four replicates each), composed of laying hens of equal body weight, which were housed at stocking densities of 580 cm2/hen and 810 cm2/hen and received 0, 1, 5 and 10 mmol/kg of tarragon (Artemisia dracunculus) in the feed, were established. At the end of the trial, 96 of the housed egg-laying hens (3 birds in each subgroup, a total of 12 birds in each group) were randomly selected and blood samples were taken from the vena subcutanea ulnaris. The samples collected were analysed for the apelin, p-BDNF, and cTnI contents. The analysis results demonstrated that tarragon supplementation had no effect on the serum apelin, p-BDNF and cTnI concentrations (P > 0.05). The Sub-Groups ST1, ST1.2, and ST6 presented with severe hyperaemia of the sinusoidal, portal and acinar blood vessels, whilst the hyperaemia of these blood vessels was moderate in Sub-Group ST12. Apelin, BDNF, and cTnI can act as protective factors against negative consequences of stress (e.g., stocking density or heat stress).
AtıfScopus5WoS7OpenAlex2İncele - MakaleAçık Erişim2020Scopus SJRQ2Effect of the addition of essential fatty acid mixture to the drinking water of the heat stress broilers on adipokine (Apelin, BDNF) response, histopathologic findings in liver and intestines, and some blood parameters
Bayraktar, Bülent; Tekce, Emre; Aksakal, Vecihi; Gül, Mehmet; Takma, Çiğdem; Bayraktar, Sevil; Bayraktar, Fatma Gülten; Eser, Gizem
The purpose of this study was to examine the effect of adding an essential fatty acid mixture (EOM; Eucalyptus globulus Labill, thymus vulgaris, Cymbopogon nardus, and Syzygium aromaticum) to the drinking water in the heat stress broilers on the adipokine (Apelin, BDNF) response, the histopathologic changes in liver and intestines, and some biochemical parameters. This study lasted for a total of 42days, including the physical exercise period (7days) and the fattening period (35days). A total of 400 Ross 308 male broilers (1-d-old) were randomly divided into 8 groups (50 animals per group), each of which was exposed to various conditions of temperature (C: 22°C and SC: 36°C) and treatment dose (C, 250, 500 and 750mL/1000 L). Each group was divided into 5 subgroups, each comprising 10 animals. In the stress-free groups, whereas the Apelin level linearly decreased, the BDNF level linearly increased. In histopathology, the liver tissue was found to be normal in all groups whereas the duodenum villi length was found to increase in the group of 750mL/1000 L. No statistically significant difference was found between the stressed groups and the non-stressed groups in terms of VLDL, Glucose, Total bilirubin, ALT, and TG (p >.05). While Apelin level increased in the stressed groups, the BDNF level increased in the group of 250mL/1000 L. In the histopathological examination, a small amount of coagulation necrosis was detected in hepatocyte, a diffuse hydropic degeneration was observed in hepatocytes, and finally a dilatation and hyperaemia were seen in sinusoid in the groups of EOM-500mL/1000 L and EOM-750 m/1000 L compared to the control group. Whereas there was no difference between the group of EOM-250mL/1000 L and the control group in terms of duodenum villa length, there was a significant decrease in other groups (p <.00). In conclusion, this study showed that adding 250mL/1000 L of EOM to the drinking water had a positive effect on the serum levels of Apelin and p-BDNF in the groups exposed to stress (p <.05).HIGHLIGHTS Heat stress results in serious annual economic losses in the poultry industry. Essential oil fatty mix acids have positive effects on poultry health. Apelin and BDNF may be a protective factor against deleterious consequences of chronic exposition to heat stress.
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