Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYalnız künye2023Scopus SJRQ1Comparison of bioactive constituents by HPLC–DAD–ESI-MS and UFLC and in vitro antioxidant activities of blossom honey, bee pollen, and propolis
Saroğlu, Öznur; Ecem Bayram, Nesrin; Özçelik, Beraat
The aim of this study was to analyze the total phenolic content, phenolic profile, and antioxidant activity of honey, bee pollen, and propolis samples from Turkey's Black Sea Region. The total phenolic content of these bee products was found using Folin–Ciocalteu's method, and their antioxidant capacity was found using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cupric ion reducing antioxidant capacity (CUPRAC) assays. Phenolic compounds of honey samples were characterized by high-performance liquid chromatography coupled to a photodiode array detector and mass spectrometer (HPLC–DAD–ESI-MS), while phenolic compounds of bee pollen and propolis samples were quantified ultra-fast liquid chromatography (UFLC). The total phenolic values for honey, bee pollen and propolis were 6.32–18.21 mg GAE/100 g, 547.64–769.4 mg GAE/100 gr, and 6096.1–11,564 mg GAE/100 gr, respectively. DPPH and CUPRAC values of honey, pollen and propolis were 11.05–21.38% and 0.38–1.48 µmol Trolox/g; 24.67–38.63% and 0.03–0.05 mmol Trolox/g; 11.81–34.12% and 0.47–0.89 mmol Trolox/g, respectively. About 30 different phenolic compounds were identified as quantitative. Our findings have shown that all bee products examined in the study are found to contain gallic acid, naringenin, and caffeic acid. In terms of total phenolic content and antioxidant activity, the bee product extracts were ranked as follows: propolis > bee pollen > honey. The high concentration of phenolic compounds in propolis explains its remarkable antioxidant effect.
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İncele - Derleme MakaleAçık Erişim2023Scopus SJRQ1Natural products of relevance in the management of attention deficit hyperactivity disorder
Custódio, Luisa; Vizetto-Duarte, Catarina; Cebeci, Fatma; Özçelik, Beraat; Sharopov, Farukh; Gürer, Eda Sonmez; Kumar, Manoj; Iriti, Marcello; Sharifi-Rad, Javad; Calina, Daniela
Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.
AtıfScopus11WoS10OpenAlex11İncele - MakaleAçık Erişim2022Attitudes and Behaviors of Turkish Consumers Regarding the Olive Oil Consumption
Özçelik, Beraat; Altuntaş, Ümit; Güzel, İsmail; Yılmaz, Özlem; Uluata, Sibel
Bu çalışmanın amacı, Türk tüketicilerinin Akdeniz diyetinin önemli bir parçası olan zeytinyağı tüketimine ilişkin tutum ve davranışlarını ortaya koymak, zeytinyağının duyusal özelliklerinin tüketiciler üzerindeki etkisini ölçmek ve bu konudaki farkındalıklarını ve tutumlarını belirlemektir. Literatür araştırması doğrultusunda, tüketicilerin zeytinyağı tercihinde en çok önem verdiği özellikler ve zeytinyağı satın alma/tüketim sıklığı Türkiye'de sıklıkla mutfaklarda kullanılan zeytinyağının önemi ve mevcut durumu göz önünde bulundurularak, tüketicilerin zeytinyağı tercihinde etkili olan parametreleri değerlendirmek için incelenmiştir. Zeytinyağı tüketim ve satın alma sıklığı, ambalaj tercihi, duyusal özelliklerin önemi gibi anket soruları hazırlanmış ve anket çalışması tasarlanmıştır. Bu anket çalışmasında tüketicilerin demografik ve sosyo-ekonomik yapıları da dikkate alınmış ve elde edilen verilerin demografik özelliklerine (cinsiyet, yaş, eğitim, gelir düzeyi) göre farklılık gösterip göstermediği istatistiksel olarak tespit edilmiştir. Belirlenen tasarım doğrultusunda "VETİ" programı ile hazırlanan anket Türkiye'de yaşayan 272 kişiye uygulanmıştır. Anketin istatistiksel analizi SPSS paket programı ile gerçekleştirilmiş, verilerin analizinde frekans dağılımı ve Ki kare Öz Bu çalışmanın amacı, Türk tüketicilerinin Akdeniz diyetinin önemli bir parçası olan zeytinyağı tüketimine ilişkin tutum ve davranışlarını ortaya koymak, zeytinyağının duyusal özelliklerinin tüketiciler üzerindeki etkisini ölçmek ve bu konudaki farkındalıklarını ve tutumlarını belirlemektir. Literatür araştırması doğrultusunda, tüketicilerin zeytinyağı tercihinde en çok önem verdiği özellikler ve zeytinyağı satın alma/tüketim sıklığı Türkiye'de sıklıkla mutfaklarda kullanılan zeytinyağının önemi ve mevcut durumu göz önünde bulundurularak, tüketicilerin zeytinyağı tercihinde etkili olan parametreleri değerlendirmek için incelenmiştir. Zeytinyağı tüketim ve satın alma sıklığı, ambalaj tercihi, duyusal özelliklerin önemi gibi anket soruları hazırlanmış ve anket çalışması tasarlanmıştır. Bu anket çalışmasında tüketicilerin demografik ve sosyo-ekonomik yapıları da dikkate alınmış ve elde edilen verilerin demografik özelliklerine (cinsiyet, yaş, eğitim, gelir düzeyi) göre farklılık gösterip göstermediği istatistiksel olarak tespit edilmiştir. Belirlenen tasarım doğrultusunda "VETİ" programı ile hazırlanan anket Türkiye'de yaşayan 272 kişiye uygulanmıştır. Anketin istatistiksel analizi SPSS paket programı ile gerçekleştirilmiş, verilerin analizinde frekans dağılımı ve Ki kare testleri kullanılmıştır. Bu anket çalışması sonucunda, Türk tüketicilerin kendilerine yöneltilen sorulara verdikleri yanıtlara göre, incelenen demografik değişkenlere, "cinsiyet", "yaş" ve "eğitim durumu" ve "gelir düzeyi"ne göre istatistiksel farklılıklar bulunmaktadır.
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İncele - MakaleAçık Erişim2022Scopus SJRQ1Recovery of Polyphenols Using Pressurized Hot Water Extraction (PHWE) from Black Rosehip Followed by Encapsulation for Increased Bioaccessibility and Antioxidant Activity
Kasapoğlu, Kadriye Nur; Demircan, Evren; Gültekin-Özgüven, Mine; Kruger, Johanita; Frank, Jan; Arslaner, Ayla; Özçelik, Beraat
In this work, pressurized hot water extraction (PHWE) of hydrophilic polyphenols from black rosehip fruit was maximized using response surface methodology for simultaneous optimization in terms of extraction yield, total antioxidant capacity, total (poly)phenols, catechin, total monomeric anthocyanins, and cyanidin-3-O-glucoside. Extraction parameters, including temperature (X1: 40–80 °C) and the solvent-to-solid ratio (X2: 10–40 mL/g), were investigated as independent variables. Experimentally obtained values were fitted to a second-order polynomial model, and optimal conditions were determined using multiple regression analysis and analysis of variance. The black rosehip extract (BRE) obtained at optimized PHWE conditions was further encapsulated in biopolymer-coated liposomes and spray dried to enhance its processing and digestive stability. After reconstitution, the fabricated particles had an average size of 247–380 nm and a zeta-potential of 15–45 mV. Moreover, encapsulation provided remarkable protection of the phenolics under in vitro gastrointestinal digestion conditions, resulting in up to a 5.6-fold more phenolics in the bioaccessible fraction, which also had 2.9–8.6-fold higher antioxidant activity compared to the nonencapsulated BRE. In conclusion, PHWE in combination with a biopolymer coating is a potent method for the production of stable and safe edible natural extracts for the delivery of (poly)phenolic compounds in food and dietary supplements.
AtıfScopus20WoS19OpenAlex20
İncele - MakaleYalnız künye2021Scopus SJRQ1Orange, red and purple barberries: Effect of in-vitro digestion on antioxidants and ACE inhibitors
Şensu, Eda; Kasapoğlu, Kadriye Nur; Gültekin-Özgüven, Mine; Demircan, Evren; Arslaner, Ayla; Özçelik, Beraat
Bioactive compounds such as phenolics, anthocyanins and carotenoids were investigated in Berberis plant with purple (PB), red (RB) and orange (OB) fruits (barberries). The study was aimed to evaluate the bioaccessibility of the antioxidants and ACE (angiotensin converting enzyme) inhibitory compounds of barberry plants upon their transit through in-vitro digestion. Among barberries, (PB) exhibited the strongest antioxidant activity due to its higher phenolic and flavonoid content. The order of total phenolics and anthocyanins was PB > RB > OB. Chlorogenic acid was the main phenolic compound in all barberries even after in-vitro digestion. All barberries had similar amounts of total carotenoids (4.45 mgβ-carotene/100gDW). After in-vitro digestion, decreasing phenolics, anthocyanins and carotenoids led to a reduced antioxidant activity. Anthocyanins were found the most sensitive compounds in-vitro digestion. In terms of ACE inhibition activity, only RB exhibited ACE inhibition before (73.84%) and after (65.51%) in-vitro digestion. No ACE inhibition activity was detected at all in RB and OB samples. Leaves and branches of Berberis had also over 50% ACE inhibitory activity. To our knowledge, this is the first study on the carotenoids of barberry and the effect of in-vitro digestion on its bioactive compounds and ACE inhibitors.
AtıfScopus30WoS22OpenAlex26İncele - Derleme MakaleAçık Erişim2020Scopus SJRQ2Avocado-Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited
Salehi, Bahare; Rescigno, Antonio; Dettori, Tinuccia; Calina, Daniela; Docea, Anca Oana; Singh, Laxman; Cebeci, Fatma; Özçelik, Beraat; Bhia, Mohammed; Dowlati Beirami, Amirreza
Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado-soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.
AtıfScopus98WoS80OpenAlex103İncele