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- MakaleYalnız künye2026Scopus SJRQ1Effect of ultra-processed food consumption on premenstrual syndrome across different body mass index categories: a cross-sectional analysis
Köktürk, Seda Nur; Taş Yıldırım, Esra; Yardımcı, Hülya
Purpose – This study aimed to examine the association between ultra-processed food (UPF) consumption and premenstrual syndrome (PMS) across different body mass index (BMI) categories in women. Design/methodology/approach – A total of 480 women aged 20–49 years participated in the study between May 2024 and May 2025 in 3 cities in Türkiye. PMS symptoms were assessed using the Premenstrual Syndrome Scale (PMSS), and UPF intake was evaluated according to the NOVA classification using a food frequency questionnaire. Anthropometric measurements, including height and body weight, were taken by researchers, and BMI was calculated for each participant. Findings – The mean BMI of the participants was 24.2 ± 4.9 kg/m2, with an average daily UPF intake of 858.0 ± 133.3 g. Higher UPF intake was significantly associated with increased reporting of PMS, with 7.0% higher odds among normal-weight women, 19.0% higher odds among overweight women, and 41.0% higher odds among women with obesity. Moreover, as UPF consumption increased from the lowest (Q1) to the highest quartile (Q4), the odds of experiencing PMS symptoms were 2.65 times (OR: 2.65, %95 CI: 1.52–4.61), 2.85 times (OR: 2.85, %95 CI:1.60–4.95), and 3.07 times (OR: 3.07, %95 CI: 1.71–5.49) higher, respectively (p = 0.001). Research limitations/implications – These findings underscore a significant association between UPF consumption and PMS symptoms, particularly among women with obesity. Given the high prevalence of PMS and its substantial impact on women's well-being, dietary interventions aimed at reducing UPF intake may represent a promising approach for PMS management and prevention. Originality/value – To the best of our knowledge, this study is the first to examine the relationship between UPF intake and self-reported PMS presence across different BMI categories. 2026
- MakaleAçık Erişim2026Scopus SJRQ1Relationship between food insecurity, intuitive eating, and body mass index among adults: a cross-sectional study in Türkiye
Ünal, G.; Esgin, Özge
This study examined the relationship between food insecurity, intuitive eating, and body mass index among adults. This cross-sectional study was conducted through face-to-face interviews between January and March 2025 at a public university in Türkiye, involving 1166 students and personnel (65.7 % women; age range: 19–64 years). Participants answered the Food Insecurity Experience Scale and the Intuitive Eating Scale-2, which has four subdimensions: unconditional permission to eat, eating for physical rather than emotional reasons, reliance on hunger and satiety cues, and body-food choice congruence. Self-reported body weight and height were collected to calculate body mass index. Food insecurity was experienced by 42.7 % of participants. It was associated with lower total Intuitive Eating Scale-2, reliance on hunger and satiety cues, body-food choice congruence (controlled for sex, institutional role, and age), and eating for physical rather than emotional reasons (controlled for sex and institutional role) scores. Sex was not a moderator of the association between food insecurity and intuitive eating. There were no significant interactions between Intuitive Eating Scale-2 total and subdimensions and food security status for body mass index. Overall, our study provides empirical evidence that food insecurity is a significant factor that contributes to low levels of intuitive eating in a large sample of Turkish adults. Further studies should investigate the moderating effect of sex on the association between food insecurity and intuitive eating, while also emphasizing the role of food insecurity in the relationship between intuitive eating habits and body mass index in different populations.
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İncele - MakaleAçık Erişim2025Scopus SJRQ3Effect of Graviola Oil Extract on Anti-obesity Effect and Adipokine (Apelin and Adiponectin) Response in High Fat Diet-induced Obese Rats
Erkılıç, T. Orkun; Bayraktar, B.
Background: This study aims to investigate the anti-obesity effect of GOE with adipokine (apelin and adiponectin) response at different doses (100 and 200 mg/kg) of GOE in normal healthy and obese rats with High-fat diet (HF). Methods: In this study, 36 adult male Wistar albino rats, aged between 8-10 weeks, were used. 6 groups were created, with 6 rats in each group: Control (C), Rat group without GOE and HF application, G100 (GOE 100 mg/kg group given with oral gavage route of administration (OGRA), G200 (GOE 200 mg/kg group given with OGRA), HFC (HF control group): no HF and no GOE group), HF100 (rats receiving HF were 100 mg/kg graviola oil extract added to their diet), HF200 (rats receiving HF were 200 mg/kg graviola oil extract added to their diet). Blood samples were taken from the tail vein (vena caudalis) of all on days 0 and 60 of the study. Apelin and adiponectin levels in the serum samples were measured by ELISA method. Result: In the present study, a significant increase (p<0.01) was observed in the mean serum apelin level in the HF groups at the end of the 60 day after HF induction, while a significant decrease (p<0.01) was also detected in the adiponectin level. On the other hand, when examined in terms of BW, the most significant decrease due to GOE addition in the HF groups, i.e. the anti-obesity effect, was determined in the HFG200 mg/kg group (p<0.01). As a result, it was concluded that GOE may be safe and beneficial when administered at a dose of 200 mg/kg in obesity-induced rats.
AtıfScopus2WoS2İncele - MakaleAçık Erişim2024Scopus SJRQ2Interleukin-27 as a novel player in alleviating hepatic steatosis: Mechanistic insights from an in vitro analysis
Cho, Wonjun; Oh, Heeseung; Abd El-Aty, A.M.; Özten, Ömer; Jeong, Ji Hoon; Jung, Tae Woo
Interleukin-27 (IL-27) is a recently discovered cytokine that has been implicated in inflammatory and metabolic conditions, such as atherosclerosis and insulin resistance. However, the mechanisms by which IL-27 attenuates hepatic lipid accumulation in hyperlipidemic conditions and counteracts endoplasmic reticulum (ER) stress, a known risk factor for impaired hepatic lipid metabolism, have not been elucidated. This in vitro study was designed to examine the effect of IL-27 on hepatic lipid metabolism. The study included the evaluation of lipogenesis-associated proteins and ER stress markers by Western blotting, the determination of hepatic lipid accumulation by Oil Red O staining, and the examination of autophagosome formation by MDC staining. The results showed that IL-27 treatment reduced lipogenic lipid deposition and the expression of ER stress markers in cultured hepatocytes exposed to palmitate. Moreover, treatment with IL-27 suppressed CD36 expression and enhanced fatty acid oxidation in palmitate-treated hepatocytes. The effects of IL-27 on hyperlipidemic hepatocytes were attenuated when adenosine monophosphate-activated protein kinase (AMPK) or 3-methyladenine (3 MA) were inhibited by small interfering RNA (siRNA). These results suggest that IL-27 attenuates hepatic ER stress and fatty acid uptake and stimulates fatty acid oxidation via AMPK/autophagy signaling, thereby alleviating hepatic steatosis. In conclusion, this study identified IL-27 as a promising therapeutic target for nonalcoholic fatty liver disease (NAFLD).
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