Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Aksungur, Nurhak(1)
- Altundaş, Necip(1)
- Atukeren, Pinar(1)
- Başar, Mehmet Sinan(1)
- Beydemir, Sukru(1)
- Bilen, Zeynep(1)
- Bozkurt, Ferhat(1)
- Cakir, Ozlem(1)
- Chafik, Abdelbasset(1)
- Citgez, Bulent(1)
- Demircioglu, Mahmut Kaan(1)
- Demircioglu, Zeynep Gul(1)
- Essamadi, Abdelkhalid(1)
- Eygu, Hakan(1)
- Gulcicek, Osman Bilgin(1)
- Kara, Salih(1)
- Kaya, Elif Duygu(1)
- Korkut, Ercan(1)
- Kul, Sinan(1)
- Mavi, Ahmet(1)
- Ozguven, Muveddet Banu Yilmaz(1)
- Solak, Kübra(1)
- Söyüt, Hakan(1)
- Yanar, Karolin(1)
- Yazici, Pinar(1)
- Yağanoğlu, Mete(1)
- Yetiş Demir, Zühal(1)
- Çelik, Safinur Yildirim(1)
- Öztürk, Gürkan(1)
- Öztürk, Nurinnisa(1)
- Şimşek, Emrah(1)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ2Development of a Clinical Decision Support System Using Artificial Intelligence Methods for Liver Transplant Centers
Yağanoğlu, Mete; Öztürk, Gürkan; Bozkurt, Ferhat; Bilen, Zeynep; Yetiş Demir, Zühal; Kul, Sinan; Şimşek, Emrah; Kara, Salih; Eygu, Hakan; Altundaş, Necip
The objective of this study is to utilize artificial intelligence techniques for the diagnosis of complications and diseases that may arise after liver transplantation, as well as for the identification of patients in need of transplantation. To achieve this, an interface was developed to collect patient information from Atatürk University Research Hospital, specifically focusing on individuals who have undergone liver transplantation. The collected data were subsequently entered into a comprehensive database. Additionally, relevant patient information was obtained through the hospital’s information processing system, which was used to create a data pool. The classification of data was based on four dependent variables, namely, the presence or absence of death (“exitus”), recurrence location, tumor recurrence, and cause of death. Techniques such as Principal Component Analysis and Linear Discriminant Analysis (LDA) were employed to enhance the performance of the models. Among the various methods employed, the LDA method consistently yielded superior results in terms of accuracy during k-fold cross-validation. Following k-fold cross-validation, the model achieved the highest accuracy of 98% for the dependent variable “exitus”. For the dependent variable “recurrence location”, the highest accuracy obtained after k-fold cross-validation was 91%. Furthermore, the highest accuracy of 99% was achieved for both the dependent variables “tumor recurrence” and “cause of death” after k-fold cross-validation.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleYayıncıda açık erişim2024Scopus SJRQ3Antioxidant effect of Rosa pimpinellifolia L. fruit extract on cholestatic liver injury: an experimental study
Demircioglu, Mahmut Kaan; Demircioglu, Zeynep Gul; Cakir, Ozlem; Yanar, Karolin; Ozguven, Muveddet Banu Yilmaz; Atukeren, Pinar; Gulcicek, Osman Bilgin; Citgez, Bulent; Yazici, Pinar
BACKGROUND: Antioxidants have been considered a rational curative strategy to prevent and cure liver diseases involving oxidative stress. An acute obstructive jaundice rat model was established to investigate the in vivo hepatoprotective efficacy of Rosa pimpinellifolia L. METHODS: The experimental jaundice model was performed by binding the main bile duct in 25 male Sprague-Dawley rats. All rats were randomly divided into five groups: first group: laparotomy-sham-only, second group: biliary tract binding (control), and third, fourth, and fifth groups: treatment groups with 250, 500, and 750 mg/kg fruit extracts daily, respectively. RESULTS: Considering dosage, although there was no significant therapeutic effect in the 250 mg/kg of Rosa pimpinellifolia L. group, the best results were found in the 500 mg/kg dose group, while results in the 750 mg/kg dose group showed consistent correlation with proinflammatory response. With regard to biochemical parameters, lipid hydroperoxide level in the rat serum and liver tissue was significantly decreased in all treatment groups. Amadori products, which are one of the early markers of glycol-oxidative stress, showed statistical significance in the treatment. CONCLUSION: It was revealed that the antioxidant effect of Rosa pimpinellifolia L. was more prominent in the early stages of hepatic injury secondary to oxidative stress.
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İncele - MakaleYalnız künye2018Scopus SJRQ4Partial Purification and Some Interesting Properties of Glutathione Peroxidase from Liver of Camel (Camelus dromedarius)
Chafik, Abdelbasset; Essamadi, Abdelkhalid; Çelik, Safinur Yildirim; Solak, Kübra; Mavi, Ahmet
Climate change and increasing temperatures are global concerns. Well adapted to desert life, the camel (Camelus dromedarius) lives most of its life under high environmental stress and represents an ideal model for studying desert adaptation among mammals. Glutathione peroxidase is the principal antioxidant defense system capable of protecting cells from oxidative stress. Glutathione Peroxidase from camel liver was purified (11.64-fold purification with 1.73% yield) and characterized The molecular weight of the enzyme was estimated to be about 69 kDa by gel filtration and 34 kDa by SDS-PAGE, implying dimeric structure of the protein. An optimum temperature of 47°C and an optimum pH of 7.8 were found. This enzyme is a typical SH-enzyme that is inhibited by D,L-dithiothreitol and β-mercaptoethanol and sensitive to bivalent cations. The enzyme had common specificity toward hydroperoxides and high specificity for reduced glutathione. The Km and Vmax values for hydrogen peroxide and reduced glutathione were 0.57 and 2.10 mM and 1.11 and 0.87 U/mg, respectively. The purified enzyme contained 16 ng of selenium per mg of protein. Our results show that the camel glutathione peroxidse exhibits properties different of those reported for other mammalian species. Lower molecular weight, homodimeric structure, higher optimum temperature, relatively low optimum pH, high affinity for hydrogen peroxide at low concentration of reduced glutathione and very low content of selenium could be explained by adaptation of the camel to living in the desert under intense environmental stress.
AtıfScopus12WoS9OpenAlex11İncele - MakaleAçık Erişim2013Scopus SJRQ2Carbonic anhydrase activity from the gilthead sea bream (Sparus aurata) liver: The toxicological effects of heavy metals
Kaya, Elif Duygu; Söyüt, Hakan; Beydemir, Sukru
Many studies have shown that metal ions may lead to oxidative stress in biological systems. Accordingly, DNA damage, protein modification, enzyme inhibition and activation, lipid peroxidation and many other effects may occur in living organisms. Many different formations of metal ions may enter human cells along with water, air, and various foods, and humans are negatively affected by these conditions, either directly or indirectly. These effects may cause irreversible damage to human metabolism. In this study, the toxicological effects of heavy metals on carbonic anhydrase enzyme activity from the gilthead sea bream liver were investigated. The carbonic anhydrase enzyme was purified via affinity chromatography and had a specific activity of 6775.5 EU mg(-1). The kinetics and characteristic properties, such as optimum pH, stable pH, optimum temperature, activation energy (E-a), activation enthalpy (Delta H), Q(10), K-m, and V-max, were determined for the purified enzyme SDS-polyacrylamide gel electrophoresis showed a single band and molecular weight of the subunit was approximately 25 kDa. Cd(II), Cu(II), Ni(II) and Ag(I) inhibited the enzyme activity in vitro. The type of inhibition and K-i values for these metals were calculated from Lineweaver-Burk plots as 17.74 mM, 36.20 mM, 12.85 mM and 0.025 mM for Cd(II), Cu(II), Ni(II) and Ag(I), respectively. All the metals were noncompetitive inhibitors. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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