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- MakaleAçık Erişim2024Scopus SJRQ2Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress; [Évaluation des expressions d'ARNm de STC-1 et STC-2 chez des patients schizophrènes présentant un stress oxydatif accru]
Karabulut Uzunçakmak, Sevgi; Özcan, Halil; Dirican, Ebubekir; Tavacı Özçelik, Ayşegül
Introduction: Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters. Methods: For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions. Results: SOD activity levels were lower in patients than in healthy individuals (p = 0.0309), while the patients’ MDA levels were higher (p = 0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p = 0.1049 and p < 0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r = 0.435, p = 0.0025). According to area under the curve (AUC) values, STC-2 (AUC = 0.8332, p < 0.0001) had better diagnostic power than STC-1 (AUC = 0.6167, p = 0.1037). Conclusions: The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia.
- MakaleYalnız künye2023Scopus SJRQ3Comparison of the critical power estimated by the best fit method and the maximal lactate steady state; [Comparaison entre la puissance critique estimée par la méthode bien-être et l’état d’équilibre maximal du lactate]
As, H.; Cabuk, R.; Norouzi, M.; Balci, G.A.; Ozkaya, O.
Aims: Maximal lactate steady state (MLSS) is accepted as the gold standard method to determine the upper boundary of heavy exercise domain, while critical power (CP) is one of the most practical ways to estimate the lower boundary of severe exercise domain. However, it has been recently discussed that the upper boundary of heavy-intensity exercise domain does not equal to lower boundary of severe-intensity exercise domain. Conversely, the best individual fit method (CPfit) has recently been suggested as an accurate estimation of CP. However, there has not been a comparative evaluation of CPfit versus MLSS. The aim of this study was, therefore, to focus on the comparison of CPfit with MLSS. Methods: Eleven well-trained male cyclists participated in this study. Following the determination of maximal oxygen uptake, MLSS was determined through the performance of standard 30-minute constant work rate exercises performed on separate days. Cyclists performed four constant-load exercises lasting 2–15 minutes on different days. The data were then fitted to mathematical models to obtain CPfit. Bland-Altman plot with 95% limits of agreement (LoA) was used to measure agreement between CPfit and MLSS. Results: According to the findings, CPfit overestimated the work rate corresponding to MLSS (300 ± 38 W vs. 265 ± 39 W; P = 0.001; effect size = 3.28). Bland-Altman results showed high LoA (14 to 55.9 W) and very high bias (bias = 35 ± 10.7 W; P = 0.001; r: 0.96) between CPfit and MLSS. Conclusion: CPfit was not identical for MLSS.
AtıfScopus1WoS2OpenAlex3
İncele - MakaleYalnız künye2022Scopus SJRQ4The mediating role of self-efficacy between emotional intelligence and job satisfaction of primary school teachers; [Le rôle médiateur de l'auto-efficacité entre l'intelligence emotionnelle et la satisfaction au travail des enseignants du primaire]
Sökmen, Yavuz; Sarikaya, İsmail
Introduction: In this study, it was analyzed whether self-efficacy has a mediating role between the emotional intelligence and job satisfaction of primary school teachers. Objective: It is to test the relationships between primary school teachers job satisfaction, self-efficacy and emotional intelligence levels. Method: A path analysis was performed on a sample of 252 primary school teachers. Results: It was found that self-efficacy mediated the relationship between emotional intelligence and job satisfaction. Conclusion: Based on the findings of the study, the relationships between emotional intelligence, job satisfaction and self-efficacy were discussed in the literature and various suggestions were made to concerned future researchers and practitioners.
AtıfScopus15WoS7OpenAlex17İncele - DergiRevue Europeenne de Psychologie Appliquee
- DergiScience and Sports
- DergiAnnales Medico-Psychologiques