Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2024Etik iklim ve örgütsel vatandaşlık davranışı arasındaki ilişkide modern ahiliğin aracılık rolü: bayburt esnaf ve sanatkarları örneği
Battal, Fetullah; Yildiz, Oktay
Bu çalışmanın amacı, etik iklim ve örgütsel vatandaşlık davranışı arasındaki ilişkide modern ahilik algısının rolünü belirlemektir. Çalışmanın teori bölümünde, etik iklim, örgütsel vatandaşlık davranışı ve modern ahilik kavramsal olarak açıklanmıştır. Alan yazında bu üç değişkenle ilgili yapılan ampirik çalışmalar incelenmiş ve bu doğrultuda araştırma modeli oluşturularak hipotezler geliştirilmiştir. Hipotezlerin analiz edilebilmesi amacıyla anket tekniğiyle Bayburt ilinde faaliyet gösteren esnaf ve sanatkarlık mesleği çalışanlarından 491 adet veri alınmış ve SPSS ve AMOS programları vasıtasıyla analizler gerçekleştirilmiştir. Elde edilen sonuçlarda tüm değişkenlerin birbirlerini pozitif yönde etkilediği, modern ahilik algısının, etik iklim ve örgütsel vatandaşlık davranışı arasında kısmi aracılık etkisinin bulunduğu anlaşılmıştır.
- MakaleAçık Erişim2021Scopus SJRQ2Targeting cov-2 spike rbd and ace-2 interaction with flavonoids of anatolian propolis by in silico and in vitro studies in terms of possible covid-19 therapeutics
Güler, Halil İbrahim; Ay Şal, Fulya; Can, Zehra; Kara, Yakup; Yildiz, Oktay; Beldüz, Ali Osman; Çanakçi, Sabriye; Kolayli, Sevgi
Propolis is a multi-functional bee product rich in polyphenols. In this study, the inhibitory effect of Anatolian propolis against SARS-coronavirus-2 (SARS-CoV-2) was investigated in vitro and in silico. Raw and commercial propolis samples were used, and both samples were found to be rich in caffeic acid, p-coumaric acid, ferulic acid, t-cinnamic acid, hesperetin, chrysin, pinocembrin, and caffeic acid phenethyl ester (CAPE) at HPLC-UV analysis. Ethanolic propolis extracts (EPE) were used in the ELISA screening test against the spike S1 protein (SARS-CoV-2): ACE-2 interaction for in vitro study. The binding energy values of these polyphenols to the SARS-CoV-2 spike and ACE-2 protein were calculated separately with a molecular docking study using the AutoDock 4.2.6 program. In addition, the pharmacokinetics and drug-likeness properties of these eight polyphenols were calculated according to the SwissADME tool. The binding energy value of pinocembrin was highest in both receptors, followed by chrysin, CAPE, and hesperetin. Based on the in silico modeling and ADME (absorption, distribution, metabolism, and excretion) behaviors of the eight polyphenols, the compounds exhibited the potential ability to act effectively as novel drugs. The findings of both studies showed that propolis has a high inhibitory potential against the Covid-19 virus. However, further studies are now needed.
AtıfScopus35WoS29OpenAlex39
İncele - MakaleYalnız künye2020Scopus SJRQ2Honeys from some different regions of Azerbaijan: bioactive characteristics based on phenolic profile and antioxidant activity
Degirmenci, Atiye; Can, Zehra; Boyraci, Gulsum Merve; Yildiz, Oktay; Asadov, Elsevar; Kolayli, Sevgi
Azerbaijan is an important region for the beekeeping and honey industry. Biochemical characteristics of eleven honey samples from different regions of Azerbaijan were analyzed through measuring electrical conductivity, optical activity, moisture content, proline and diastase number. Phenolic components are analyzed by reverse-phase high-performance liquid chromatography (RP-HPLC) with UV–Vis double beam detector. Sugars profiles of samples were carried out using HPLC with a refractive index detector (RID). Total phenolic content (TPC), ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picryhydrazyl (DPPH) free radical scavenging activity were measured with the aim of gathering information on the antioxidant power of samples. Biochemical and antioxidant characteristics are also supported with melissopalynological data. Conductivity ranged between 0.32 and 0.82 mS cm−1, moisture 14.52 and 20.78%, proline 314.34 and 1077.21 mg kg−1, diastase 13.05 and 22.19. Azerbaijan honeys exhibited levorotatory properties. Total phenolic content varied from 18.82 to 154.75 mg gallic acid equivalent per 100 g honey. The results confirm that physico-chemical and biologically active properties of Azerbaijan honeys are affected by the flora and geographical variations.
AtıfScopus17WoS16OpenAlex20İncele - MakaleYalnız künye2018Scopus SJRQ2Investigating 5-hydroxymethylfurfural formation kinetic and antioxidant activity in heat treated honey from different floral sources
Turkut, G. Merve; Degirmenci, Atiye; Yildiz, Oktay; Can, Zehra; Cavrar, Sevda; Yaylaci Karahalil, Fatma; Kolayli, Sevgi
The quality and biochemical properties of honey are affected by heating or during storage period. The most important biochemical reaction that occurs in this process is the Maillard reaction. HMF (5-hydroxymethylfurfural) is one of the major intermediate products in the Maillard reaction that can lead to quality reduction in heated honey. In this study, the effect of heating on the antioxidant activity, and colour values as Maillard reaction indicators of three different botanical honeys were investigated; the HMF formation was also determined. Temperatures of 50, 70 and 80 °C were applied on the honeys between 0 and 48 h. Total phenolic content, ferric reducing/antioxidant power and scavenging of 2,2-diphenyl-1-picrylhydrazyl free radical assays are used to determine the antioxidant capacity. Results showed that the formation of HMF and the antioxidant properties of honeys were significantly increased during the heating process. Pure HMF compound also showed lower antioxidant activity. The formation of HMF has higher degree of linearity in the fit of the zero order reaction and also it was the highest in the chestnut honey. Furthermore, it was found that as the biochemical value of the honeys increased, the HMF formation decelerated.
AtıfScopus45WoS35OpenAlex44İncele