Sürdürülebilir Kalkınma Amaçları
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- MakaleYalnız künye2026Scopus SJRQ2Hot injection synthesis of metal-doped Ag2S nanocrystals: A novel multifunctional approach for cancer therapy, antibacterial strategies, and antioxidant defense
ULUSU, Funda; OZEL, Sultan Suleyman; Sarilmaz, Adem; ULUSU, Yakup
This pioneering study presents the synthesis and comprehensive evaluation of bare and metal-doped Ag₂S nanocrystals (NCs) as multifunctional agents with potential applications in antibacterial, antioxidant, and anticancer therapies. The incorporation of manganese, nickel, cobalt, and zinc into Ag₂S NCs resulted in a notable enhancement of their bioactivity, representing a novel approach in nanomaterial design. The antibacterial assessments revealed that Mn:Ag₂S NCs were the most potent candidate, exhibiting exceptional activity against S. aureus and E. coli, with the lowest MIC values recorded at 1.28 mg/mL and 1.08 mg/mL, respectively. The antioxidant studies demonstrated that the Mn:Ag₂S NCs exhibited remarkable free radical scavenging and ferric reducing capacities, with the lowest IC50 values (22.69 µg/mL for DPPH and 61.31 µg/mL for FRAP) underscoring their potential to mitigate oxidative stress. Importantly, cytotoxicity assays revealed that Ni:Ag₂S and Mn:Ag₂S nanocrystals selectively inhibited the proliferation of human colon cancer cells (HT-29), achieving IC50 values of 61.51 µg/mL and 90.12 µg/mL, respectively. Furthermore, these NCs demonstrate reduced toxicity towards mouse fibroblast cells (L929). This selective cytotoxicity indicates the potential of these agents in targeted cancer therapies, thereby reducing damage to healthy tissues. To the best of our knowledge, this is the first study to systematically explore the synergistic effects of metal doping on the multifunctional properties of Ag₂S NCs. These findings provide a robust basis for further in vivo studies and offer new avenues for the development of safe and effective nanomaterials in biomedical applications, particularly as antimicrobial, antioxidant, and anticancer agents.
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İncele - MakaleAçık Erişim2025Scopus SJRQ2Advancing perovskite solar cells: Inorganic CCTS hole-transporting material for enhanced efficiency and stability
Sari, Fahriye; Ozel, Sultan Suleyman; Sarilmaz, Adem; Ozel, Faruk; Kus, Mahmut; Ersoz, Mustafa
One of the most effective methods for generating renewable energy is the efficient conversion of photons into electrical energy using environmentally sustainable materials. In recent years, the integration of chalcogenide materials, which exhibit graphene-like semiconducting properties and high charge carrier mobility, into perovskite solar cells (PSCs) has garnered significant attention for enhancing the performance, stability, and eco-friendly nature of these devices. In this study, Cu₂CoSnS₄ (CCTS) nanocrystals were synthesized and utilized as a fully inorganic hole transport layer (HTL) in inverted PSCs. Devices incorporating 6 vol% CCTS achieved a power conversion efficiency (PCE) of 10.07 %, and retained 93 % of their initial efficiency after 720 h under inert storage conditions, without encapsulation. This demonstrates a notable improvement in stability compared to conventional PEDOT: PSS-based devices. The optimized CCTS HTL provided better energy level alignment, reduced moisture ingress, and enhanced charge transport. These findings indicate that CCTS is a promising inorganic HTL candidate for efficient and stable PSCs.
AtıfScopus5WoS5OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ3The performance of Ag2S/X (X: Co and Ni) nanocrystals as counter electrodes in dye-sensitized solar cells
Ozel, Sultan Suleyman; Bulucu, Esen Dagasan; Sarilmaz, Adem; Ozel, Faruk
In the present study, Silver sulfide (Ag2S)-based nanocrystals (NCs) were synthesized by employing a facile hot injection method. These NCs are utilized as counter electrodes on dye-sensitized solar cells (DSSCs), representing a smart approach that utilizes these NCs as catalysts instead of platinum (Pt) for the first time. The study provides a comparative analysis of the performance of Ag2S-based counter electrodes (CEs) in DSSCs technologies the traditionally compared Pt-based electrodes under identical conditions. The findings showed that the Ag2S-based DSSCs exhibited a power conversion efficiency (ƞ) that was approximately 5.2 % higher than that of the platinum-based DSSCs. Consequently, the results of this study demonstrate that Ag2S-based NCs possess the potential to function as novel counter electrode materials for low-cost, Pt-free solar cells. Moreover, the results of this study bear considerable implications for the development of cost-effective and sustainable solar energy solutions. The advent of Ag2S-based NCs signifies a significant milestone in the quest for sustainable and efficient energy solutions. This study also invites further exploration into other potential material combinations and synthesis methods that could enhance the properties and performance of DSSCs.
AtıfScopus4WoS3OpenAlex3İncele - MakaleYalnız künye2024Scopus SJRQ1Investigation of antibacterial activities of copper based multinary sulfide alloys
Kurt, Hacer; Çekceoğlu, İlknur Aksoy; Acar, Eminegül Genc; Aslan, Emre; Ozel, Sultan Suleyman; Sarilmaz, Adem; Patir, İmren Hatay
One of the nanomaterial-based antimicrobials, CuS, has emerged as a potential active therapeutic agent to combat biofilm infections, showing superior antibacterial activity with both photothermal and photodynamic effects under NIR illumination. To investigate the influence of transition metals on the antibacterial activity of CuxS, the antibacterial properties of shape- and phase- controlled copper-based multinary sulfide (M: CuxS (M: Mn, Zn and Ni)) nanostructures prepared by hot injection method were investigated against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli under NIR light irradiation. It has been shown that CuxS-based nanomaterials suppress bacterial growth under NIR light irradiation and that, in addition to their antibacterial activity, they also exhibit a remarkable ability to form biofilms. The antibiofilm efficacy of the M:CuxS (M: Mn, Zn and Ni) nanocomposites was significantly higher than that of bare CuS, resulting in biofilm inhibition with rates of 52.53 %, 62.24 % and 74.48 % on E. coli for Mn:CuxS, Zn:CuxS and Ni:CuxS, respectively. In addition, the biofilm of S. aureus was more affected by treatment with M:CuxS (M: Mn, Zn and Ni) nanocomposites, with biofilm activity of 64.15 %, 68.42 % and 87.35 % for Mn:CuxS, Zn:CuxS and Ni:CuxS, respectively. Ni:CuxS showed the highest antibacterial activity, which is attributed to smaller crystal and particle size and energy band gap, resulting in a larger number of nanoparticles per unit volume, a larger surface area and a stronger tendency to electrostatically bind to bacterial cell membranes, a faster ability to penetrate channels and stronger absorption in the NIR range. This work points the way for a broad application of CuS-based biocompatible synergistic antibacterial nanocomposites and can also serve as a guide for antibacterial/antibiofilm approaches as an alternative to conventional antibiotic treatments.
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