Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ2Evaluation of post-traumatic stress disorder and food insecurity in earthquake survivors
Köktürk, Seda Nur; Esgin, Özge; Bulbul, Ali Savas; Sahin, Engin
Aim: This study aimed to investigate the psychological difficulties and challenges related to food insecurity following the earthquakes in Kahramanmaraş province on February 6, 2023, particularly examining the relationship between Post-Traumatic Stress Disorder (PTSD) and food insecurity among survivors. Subjects and methods: The research included 504 adults (71.4% female). The study assessed the subcomponents of food insecurity and measured PTSD levels among participants. It also evaluated the prevalence of Gastrointestinal System (GIS) issues and appetite loss. Results: Individuals facing food insecurity exhibited higher median PTSD scores compared to those not experiencing food insecurity. A significant majority of individuals with PTSD (90.2%) also encountered GIS issues, with a notable prevalence of appetite loss. GIS problems were common among those experiencing food insecurity. Conclusion: Many disaster victims endure both food insecurity and PTSD, negatively impacting their dietary habits and health. Providing clean, dependable, and nutritious food post-disaster can reduce health risks. Psychological support and therapy for PTSD can aid recovery. More detailed studies on nutritional status are needed for deeper insights.
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İncele - MakaleAçık Erişim2021Lactobacillus paracasei biyokatalizörü ile enantiyosaf (S)-1- (4-metoksifenil) etanol üretimi
Sahin, Engin
Bu çalışmada, 4-metoksiasetofenonun enantiyoseçici indirgenmesinde yedi biyokatalizörün indirgeme kapasitesi tam hücre biyokatalizör olarak araştırılmıştır. Lactobacillus paracasei BD28'in en iyi indirgeme kapasitesine sahip olduğu bulunmuştur. pH, inkübasyon süresi, çalkalama hızı ve sıcaklık gibi farklı parametrelerin enantiyomerik aşırılık ve dönüşüm üzerindeki etkileri araştırıldı. Tam hücre biyokatalizörü Lactobacillus paracasei BD28 kullanılarak, genel alerjik yanıt için tedavi fonksiyonuna sahip sikloalkil [b] indollerin sentezinde kullanılabilen (S)-1-(4-metoksifenil) etanol, gram ölçeğinde, yüksek verimli ve enantiyomerik olarak saf halde üretilmiştir. Gram ölçekli üretim gerçekleştirildi ve % 95 verimle optik olarak saf formda 9,69 g (S)-1-(4-metoksifenil) etanol üretildi. Bu, kimyasal işlemlere kıyasla (S)-1-(4-metoksifenil) etanol üretimi için ucuz, temiz ve çevre dostu bir işlemdir.
- MakaleYalnız künye2017Lactobacillus curvatus Suşu ile Asetofenon Türevlerinin Asimetrik İndirgenmesi
Sahin, Engin
Sekiz farklı Lactobacillus curvatus suşu asetofenon'un 1-fenil etanol'e asimetrik indirgenmesinde biyokatalizör olarak değerlendirildi. Test edilen bu laktik asit bakteri (LAB) suşları arasında Lactobacillus curvatusN5asetofenon'un enantiyoseçici indirgenmesinde en etkili biyokatalizör olarak bulundu. Optimize edilen reaksiyon şartları altında asetofenon türevleri % 99 enantiyomerik fazlalığa kadar ilgili kiral sekonder alkollere dönüştürüldü.
- MakaleYalnız künye2011Scopus SJRQ1Synthesis of sterically constrained tricyclic pyrrolidinyl alcohol ligands for the enantioselective ethylation of aryl aldehydes: Assessment of the influence of ring strain and N-alkyl chain length on asymmetric induction
Sahin, Engin; Kilic, Hamdullah
A series of chiral sterically constrained tricyclic pyrrolidinyl alcohol ligands were synthesized from the appropriate amino acids, and a comparative study of the activity and selectivity of the ligands for the enantioselective ethylation of aromatic aldehydes was carried out. The results obtained were compared with those previously reported for related monocyclic analogues; it was found that the bicyclo[2.2.2]octane backbone fused to pyrrolidine and the groups attached to the carbinol centre, as well as the chain length of the β-amino alcohol, had a marked effect on the enantioselectivity. The enantioselective addition of dialkylzincs to aryl aldehydes in the presence of ligands with diethyl substituents on the carbinol carbon afforded (R)-sec-alcohols in up to 99% enantiomeric excess (ee).
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