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Mechanism of capsaicin inhibition of aldose reductase activity

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Özet

Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway.

Anahtar Kelimeler

aldose reductasecapsaicindiabetic complicationsinhibition
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/bayburt/12443Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1002/jbt.21898Yayıncı resmi DOI adresi
İndeks kayıtları
ScopusScopusWeb of ScienceWeb of SciencePubMedPubMed
Kaydın indeks veri tabanlarındaki sayfası (aktarımda alınan kayıt numarasıyla). Erişim, indeksin kendi koşullarına bağlıdır.
Atıflar
Scopus
21
WoS
19
OpenAlex
24
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Tam Kayıt
AlanDeğerDil
dc.contributor.authorAlim, Zuhal
dc.contributor.authorKilinc, Namık
dc.contributor.authorSengul, Bulent
dc.contributor.authorBeydemir, Sukru
dc.date.accessioned2026-10-29T19:09:35.325836450Z
dc.date.available2026-10-29T19:09:35.325836450Z
dc.date.issued2017
dc.description.abstractAldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway.
dc.identifier.articlenumbere21898
dc.identifier.doi10.1002/jbt.21898
dc.identifier.eissn1099-0461
dc.identifier.issn1095-6670
dc.identifier.issue7
dc.identifier.pmid28217947
dc.identifier.scopus2-s2.0-85013411153
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/bayburt/12443
dc.identifier.volume31
dc.identifier.wosWOS:000405321900004
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectaldose reductase
dc.subjectcapsaicin
dc.subjectdiabetic complications
dc.subjectinhibition
dc.subject.classificationBiochemistry & Molecular Biology
dc.subject.classificationToxicology
dc.subject.otherAldehyde Reductase
dc.subject.otherAnimals
dc.subject.otherCapsaicin
dc.subject.otherDose-Response Relationship, Drug
dc.subject.otherEnzyme Inhibitors
dc.subject.otherMale
dc.subject.otherOrgan Specificity
dc.subject.otherRats
dc.subject.otherRats, Sprague-Dawley
dc.subject.otherenzyme inhibitor
dc.subject.otheranimal tissue
dc.subject.otherArticle
dc.subject.otherbrain
dc.subject.othercontrolled study
dc.subject.otherdrug efficacy
dc.subject.otherdrug mechanism
dc.subject.otherenzyme activity
dc.subject.otherenzyme inhibition
dc.subject.otherheart
dc.subject.otherin vitro study
dc.subject.otherkidney
dc.subject.otherliver
dc.subject.othernonhuman
dc.subject.otherrat
dc.subject.otheranimal
dc.subject.otherantagonists and inhibitors
dc.subject.otherantibody specificity
dc.subject.otherdose response
dc.subject.othermetabolism
dc.subject.otherSprague Dawley rat
dc.titleMechanism of capsaicin inhibition of aldose reductase activity
dc.typeArticle
rdl.citation.openalex24
rdl.citation.scopus21
rdl.citation.wos19
rdl.departmentDepartment of Chemistry, Faculty of Science and Arts, Ahi Evran University, 40000, Kırşehir, Turkey
rdl.departmentDepartment of Medical Services and Techniques, Vocational School of Health Service, Iğdır University, 76000, Iğdır, Turkey
rdl.departmentDepartment of Health Care Service, Vocational School of Health Service, Bayburt University, 69000, Bayburt, Turkey
rdl.departmentDepartment of Chemistry, Faculty of Sciences, Atatürk University, 25240, Erzurum, Turkey
rdl.departmentDepartment of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey
rdl.oa.statusclosed
rdl.scopus.quartileQ2
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)