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The anti-genotoxic effect of some lichenic acids

MakaleAçık ErişimScopus SJRQ3
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 μgmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 μgmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid.

Anahtar Kelimeler

Antigenotoxic activityComet assayDiffractaic acidLecanoric acidLichen compoundsLobaric acidVulpinic acid
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/bayburt/12247Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.4038/jnsfsr.v46i2.8423Yayıncı resmi DOI adresi
İndeks kayıtları
ScopusScopusWeb of ScienceWeb of Science
Kaydın indeks veri tabanlarındaki sayfası (aktarımda alınan kayıt numarasıyla). Erişim, indeksin kendi koşullarına bağlıdır.
Atıflar
Scopus
4
WoS
2
OpenAlex
2
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Tam Kayıt
AlanDeğerDil
dc.contributor.authorKizil, Hamit Emre
dc.contributor.authorCeker, Selcuk
dc.contributor.authorCapik, Ozel
dc.contributor.authorAgar, Guleray
dc.date.accessioned2026-10-29T19:09:21.878528104Z
dc.date.available2026-10-29T19:09:21.878528104Z
dc.date.issued2018
dc.description.abstractFour lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 μgmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 μgmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid.
dc.identifier.doi10.4038/jnsfsr.v46i2.8423
dc.identifier.eissn2362-0161
dc.identifier.endpage231
dc.identifier.issn1391-4588
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85049533989
dc.identifier.startpage227
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/bayburt/12247
dc.identifier.volume46
dc.identifier.wosWOS:000438990400013
dc.language.isoen
dc.publisherNational Science Foundation
dc.relation.ispartofJournal of the National Science Foundation of Sri Lanka
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntigenotoxic activity
dc.subjectComet assay
dc.subjectDiffractaic acid
dc.subjectLecanoric acid
dc.subjectLichen compounds
dc.subjectLobaric acid
dc.subjectVulpinic acid
dc.subject.classificationMultidisciplinary Sciences
dc.subject.classificationScience & Technology - Other Topics
dc.subject.otherDIFFRACTAIC ACID
dc.subject.otherDNA-DAMAGE
dc.subject.otherMETABOLITES
dc.subject.otherANTIOXIDANT
dc.titleThe anti-genotoxic effect of some lichenic acids
dc.typeArticle
rdl.citation.openalex2
rdl.citation.scopus4
rdl.citation.wos2
rdl.oa.statusgold
rdl.oa.urlhttps://doi.org/10.4038/jnsfsr.v46i2.8423
rdl.scopus.quartileQ3
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)