Sürdürülebilir Kalkınma Amaçları

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• MakaleYalnız künye2026Scopus SJRQ3/r/bayburt/11344
  Synthesis and cytotoxic activity studies of novel heterocyclic thiosemicarbazone compounds as anticancer agents

  Güllü, Eda; Hasanoğlu Özkan, Elvan; Kızıl, Hamit Emre; Nartop, Dilek

  Herein, novel heterocyclic thiosemicarbazone compounds (Hb1, Hb2, Hb3) containing pyrimidine, imidazole, pyridine, and phenyl rings were synthesized via the condensation method as potential therapeutic agents for the treatment of non-small cell lung cancer. The structure of novel heterocyclic compounds was elucidated by using some spectroscopic techniques (organic elemental analysis, fourier transform infrared spectroscopy, proton/carbon nuclear magnetic resonance spectroscopy, scanning electron microscopy and energy dispersive X-ray image, and molar conductance measurement). The antiproliferative activity of novel heterocyclic thiosemicarbazone compounds using CVDK-8 cell viability assay. The viability assay was examined against A549 human non-small cell lung cancer cell line. All heterocyclic thiosemicarbazone compounds exhibited varying degrees of dose-dependent cytotoxic activity against A549 NSCLC cells. The results showed that the pyridine-based heterocyclic compound (Hb3) was the most potent antiproliferative agent, demonstrating a dose-dependent reduction in cell viability at concentrations of 50 µg/mL and higher.

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• MakaleAçık Erişim2015Scopus SJRQ4/r/bayburt/12473
  Synthesis, characterization and complexation properties of a novel Mg-porphyrazine with metal ions in acetonitrile-chloroform

  Kabay, Nilgün; Baygu, Yasemin; Gök, Yaşar; Başoʇlu, Aysel; Ocak, Ümmühan

  The synthesis and characterization of a novel metal derivative of a peripherally symmetrically tetra-substituted porphyrazine derived from 25,26-dioxa-6,7,9,10,15,16,18,19-octahydro-25H-1,24-methanodibenzo[q,t][1,4,13,16,17,10]tetraoxadithiacyclohenicosine-12,13-dicarbonitrile was carried out. The influence of metal cations such as Zn2+, Fe2+, Mn2+, Ni2+, Co2+, Hg2+ and Cu2+ on the spectroscopic properties of the ligands, the starting material dinitrile and MgPz were investigated in acetonitrile-chloroform solution (1/1) by means of absorption spectrometry. Absorption spectra showed isosbestic points in the spectrophotometric titration of Cu2+ and Hg2+ with MgPz ligand. The results of spectrophotometric titration experiments disclosed the complex stability constant of the novel ligand, MgPz with Cu2+ and Hg2+ cations.

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