Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2025Scopus SJRQ3/r/bayburt/12805
  Revealing the Behavioral Effects of Hair Dye Exposure in Rats by Sociability, Anxiety and Recognition Assessments

  Boyuk Ozcan, G.; Bozok, U.G.; Korkusuz, B.B.; Demirboga, B.; Rabetian, S.; Orkun Erkilic, T.

  Background: Most people use hair dye to change their hair color. The aim of this study was to investigate how hair dye affects rat behavioral tests. Methods: This study examines the effects of hair dye exposure on the Three-Chambered Sociability, open field, elevated plus maze and novel object recognition tests. Group 1 (n=8) was dyed twice, Group 2 (n=8) was dyed four times, Group 3 (n=8) was dyed eight times and Group 4 (n=8) was water-treated and dried eight times. Result: The control group (Group 4) sniffed certain objects more in the first occupied cage. The groups exposed to less dye explored for longer periods (p<0.05 higher in Groups 1 and 2 than in the control group). In the open field test, Group 2 showed more scratching, hunger and urination. The control group showed more cage interaction than the other groups (p<0.05). In the elevated plus maze test, no difference in time was found between the groups. In conclusion, hair dye chemicals may affect rat behavior, but neurotoxicity and oxidative stress tests are required to confirm this.

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• MakaleAçık Erişim2025Scopus SJRQ3/r/bayburt/11825
  Effect of Moringa oleifera Oil Extract on Adipokine (Apelin, Visfatin and Nesfatin-1) and Cardiac (cTnI) Response in Streptozotocin-induced Rats

  Orkun Erkiliç, Tuğçe; Bayraktar, Bülent

  Background: The aim of this study was to investigate the effects of Moringa oleifera extract (MOE) added to the diets at different amounts on Adipokine (apelin, visfatin and nesfatin-1) and Cardiac (cardiac troponin I (cTnI)) Response in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. Eight (8) groups were created, with 8 rats in each group: Control (C), M100 (MOE 100 mg/kg group given with oral gavage route of administration (OGRA), M200 (MOE 200 mg/kg group given with OGRA), M300 (MOE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, Diabetic control group (DC), DM100 (D+100 mg/kg MOE), DM200 (D+200 mg/kg MOE), DM300 (D)+300 mg/kg MOE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (Vena caudalis) of all subMects on days 0 and 21 of the study. Apelin, visfatin, nesfatin-1 and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, the most significant increase in mean serum apelin, visfatin, nesfatin-1 and cTnI levels in diabetes groups was observed in DC groups, while the most significant decrease due to MOE addition was observed in DM200 groups (p<0.01). As a result, it was concluded that MOE may be safe and beneficial when administered at a dose of 200 mg/kg in rats with STZ-induced diabetes.

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  AtıfScopus3·WoS4

  İncele
• MakaleAçık Erişim2025Scopus SJRQ3/r/bayburt/11328
  Effect of Graviola Oil Extract on Anti-obesity Effect and Adipokine (Apelin and Adiponectin) Response in High Fat Diet-induced Obese Rats

  Erkılıç, T. Orkun; Bayraktar, B.

  Background: This study aims to investigate the anti-obesity effect of GOE with adipokine (apelin and adiponectin) response at different doses (100 and 200 mg/kg) of GOE in normal healthy and obese rats with High-fat diet (HF). Methods: In this study, 36 adult male Wistar albino rats, aged between 8-10 weeks, were used. 6 groups were created, with 6 rats in each group: Control (C), Rat group without GOE and HF application, G100 (GOE 100 mg/kg group given with oral gavage route of administration (OGRA), G200 (GOE 200 mg/kg group given with OGRA), HFC (HF control group): no HF and no GOE group), HF100 (rats receiving HF were 100 mg/kg graviola oil extract added to their diet), HF200 (rats receiving HF were 200 mg/kg graviola oil extract added to their diet). Blood samples were taken from the tail vein (vena caudalis) of all on days 0 and 60 of the study. Apelin and adiponectin levels in the serum samples were measured by ELISA method. Result: In the present study, a significant increase (p<0.01) was observed in the mean serum apelin level in the HF groups at the end of the 60 day after HF induction, while a significant decrease (p<0.01) was also detected in the adiponectin level. On the other hand, when examined in terms of BW, the most significant decrease due to GOE addition in the HF groups, i.e. the anti-obesity effect, was determined in the HFG200 mg/kg group (p<0.01). As a result, it was concluded that GOE may be safe and beneficial when administered at a dose of 200 mg/kg in obesity-induced rats.

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  AtıfScopus2·WoS2

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• MakaleAçık Erişim2025Scopus SJRQ3/r/bayburt/11011
  EffectofJackfruıtPulpExtractonSerumNesfatın-1andVısfatın Levels in Streptozotocın-induced Rats

  Erkılıç, T. Orkun; Bayraktar, B.

  Background: The aim of this study was to investigate the effects of different amounts of jackfruit pulp extract (JPE) in the diets on serum nesfatin-1 and visfatin levels in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. 8 groups were created, with 8 rats in each group: Control (C), J100 (JPE 100 mg/kg group given with oral gavage route of administration (OGRA), J200 (JPE 200 mg/kg group given with OGRA), J300 (JPE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, DJ100 (D+100 mg/kg JPE), DJ200 (D + 200 mg/kg JPE), DJ300 (D). + 300 mg/kg JPE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (Vena caudalis) of all subjects on days 0 and 21 of the study. Nesfatin-1 and visfatin levels in the serum samples were measured by ELISA method. Result: As a result, in the diabetes groups of our study, the most significant increase in the mean serum nesfatin-1 level and the most significant decrease in the mean serum visfatin level occurred in the DJ200 groups at the end of the 21st day due to the addition of JPE (p<0.05). As a result, it was concluded that JPE may be safe and beneficial when administered at a dose of 200 mg/kg in diabetic groups.

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  AtıfScopus6·OpenAlex1

  İncele
• MakaleAçık Erişim2025Scopus SJRQ3/r/bayburt/10940
  The Effect of Cannabidiol on Myokine, Cerebral and Cardiac Response in Rats with Sepsis Induced by Cecal Ligation and Punture Method

  Erkiliç, T. Orkun; Bayraktar, B.

  Background: The aim of this study was to investigate the effects of Cannabidiol on myokine (Irisin), cerebral (BDNF) and cardiac (cTnI) responses in sepsis-induced rats by Cecal Ligation Perforation (CLP) method. Methods: In this study, 40 adult male Wistar albino rats, aged between 8-10 weeks, were used. 5 groups were created, with 8 rats in each group: Control (C), Sham (S), CLP, CLP+CBD 2.5 mg/kg, CLP+CBD 5 mg/kg group. Rats in groups C and Sham were sacrificed at the end of the 10th hour and intracardiac blood was taken immediately afterwards. In groups CLP, CLP+2.5 mg/kg, CLP+5 mg/kg, intra-abdominal sepsis was induced and at the end of the 10th hour after sepsis occurred with CLP application, rats were sacrificed and intracardiac blood was taken immediately afterwards. İrisin, BDNF and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, mean serum irisin, BDNF and levels were determined to be at the lowest level in the CLP group, while cTnI levels were at the highest level (p<0.01). In CLP groups, serum irisin and BDNF levels increased due to CBD addition and the most significant decrease in cTnI levels occurred in 5 mg/kg CBD groups. As a result, it was concluded that CLP may be safe and beneficial when administered at a dose of 5 mg/kg in sepsis-induced rats.

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  AtıfScopus2·WoS2

  İncele
• MakaleAçık Erişim2024Scopus SJRQ3/r/bayburt/13098
  Effect of Different Rates of Rambutan Peel Extract on Visfatin and Cardiac Troponi N I Response in Type 2 Diabetic Rats Induced with Streptozotocin

  Çelikel Taşci, S.; Bayraktar, B.; Bülbül, A.S.; Sait, A.; Korkmaz, S.

  Background: The aim of this study was to investigate the effects of STZ (Streptozotocin) and Rambutan peel extract (RPE) on serum visfatin and cardiac response in experimental Type 2 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. 8 groups were randomly selected, each containing 8 rats as Control (C), R100 (RPE 100 mg/kg group given with oral gavage route of administration (OGRA), R200 (RPE 200 mg/kg group given with OGRA), R300 (RPE 300 mg/kg group given with OGRA); Diabetes Control (DC): STZ 50 mg/kg i.p administered group, DR100 (D+100 mg/kg JPE), DR200 (D+200 mg/kg JPE), DR300 (D+300 mg/kg JPE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (vena caudalis) of all subjects on days 0 and 21 of the study. Visfatin and cTnI levels in the serum samples were measured and evaluated by ELISA method. Result: While the increase in mean serum visfatin and cTnI levels in diabetic groups was seen mostly in DC groups, the most significant decrease in mean serum visfatin level due to the addition of RPE was determined in DR100 groups (p<0.01). As a result, it was concluded that the administration of 100 mg/kg RPE in rats had no adverse effects. It was concluded that RPE, which has a cardioprotective effect by regulating the visfatin response that plays a role in the development of diabetes, may be useful in supporting the impaired cardiovascular system function that occurs in diabetes.

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  AtıfScopus7·WoS7·OpenAlex2

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• MakaleAçık Erişim2024Scopus SJRQ3/r/bayburt/12953
  The Relationship of Mitochondrial-derived Peptide (MOTS-c) and Brain Mitochondrial Carrier Protein 1 (BMCP1) Response in Sheep with Some Physiological Parameters

  Bayraktar, B.; Demir, N.; Aksakal, V.

  Background: Mitochondria are organelles called power plants of the cell, which are found in eukaryotic cells and are responsible for the production of energy needed by the cells through aerobic respiration. Mitochondrial dysfunction causes endocrinological, cardiovascular, metabolic and neurodegenerative diseases. The aim of this study was to examine the effects of body condition score (BCS), lactation, pregnancy, age and gender on Mitochondrial-Derived Peptide (MOTS-c) and Brain Mitochondrial Transporter Protein 1 (BMCP1) levels in Akkaraman sheep. Methods: Sheep are classified into 3 categories according to BCS (BCS<2, BCS=3-3.5, BCS≥4). In creating groups in terms of BCS, it was determined by the palpation method applied to the waist area. The sheep included in the study were divided into 4 groups: early lactation, early pregnancy, late pregnancy (dry period) and age (female and male sheep).1st group, ewes in the first period of pregnancy (on the 100th day of the first pregnancy) (n= 30), 2nd group, ewes in the early lactation period (n= 30), 3rd group, ewes in the dry period (the last two months of pregnancy) (n= 30) and in the 4th group, <2 (young) (n=30), 2-8 (adult) (n=30), 8> (old) (n=30), male and female sheep (n=30) of different ages. =180) total of 270 animals. Blood samples were taken from the jugular vein of the sheep before the morning feeding. MOTSc and BMCP1 levels were determined in blood serum samples by ELISA method. Result: In the study, serum MOTS-c and BMCP1 levels in sheep during lactation and pregnancy were determined to be lowest in the VKS<2 group and highest in the VKS ≥4 groups. Likewise, in age and gender groups, the highest level was detected in young lambs and yearlings in the VKS<2 group, while the highest level was detected in old sheep and rams in the VKS ≥4 group. As a result, it was determined that different age, gender, pregnancy and lactation periods affected serum MOTS-c and BMCP1 levels depending on the change in BCS (P<0.05). It was concluded that MOTS-c and BMCP1 may be useful parameters in the evaluation of mitochondrial function, energy metabolism and metabolic profile.

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  AtıfScopus4·WoS4·OpenAlex2

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• MakaleAçık Erişim2024Scopus SJRQ3/r/bayburt/11838
  Investigation of Microbiological, Physiological and Histopathological Changes in Polymicrobial Infection in Old Rats

  Ülker, U.; Kızıl, S.; Bayraktar, B.; Alçığır, M.E.; Kul, O.; Kaya, H.; Ürüşan, H.; Aydemir, Ş.; Kotan, G.C.; Önel, A.U.

  Background: The aim of this study is to examine the microbiological, clinical, physiological and pathological findings of natural polymicrobial infection developing in a wistar rat colony under long-term observation. Methods: In this study, 70 male Wistar albino rats, 3 years old, raised by conventional methods and housed in a cage environment were used. Thirteen rats with clinical symptoms such as torticollis and rotation were sacrificed for microbiological and histopathological examination after 14 days. For microbiological examination, the rapid diagnostic kit BBL Crystal system was used to identify bacterial agents in tissue and stool samples and the traditional culture method was used for isolation. Result: As a result of microbiological analysis, the rarely isolated Staphylococcus capitis (S. capitis) was isolated. Different Staphylococcus spp. It has been determined that the species can cause suppurative meningoencephalitis as well as septicemia in the brains of experimental animals., it is thought that polymicrobial infection will be useful for the identification of bacterial agents and infection prevention and treatment strategies.

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  İncele
• MakaleAçık Erişim2018Scopus SJRQ2/r/bayburt/13900
  The effect of apple cider vinegar and mushroom stalk supplementation on laying hens

  Karaalp, Musa; Aksakal, Vecihi; Sarikaya, Sevim Beyza Ozturk; Urusan, Hilal; Bayram, Bahri; Zulkadir, Ayhan

  The aim of this trial was to study the effects of consuming water with apple cider vinegar (ACV) and feed including mushroom (Agaricus bisporus) stalk (MS) on performance and certain egg characteristics. The hens were separated into four treatment groups (with 4 replicates and 6 hens per replicate). The experimental groups were control (not consumed ACV and MS), ACV (3 ml/l drinking water), MS (20 g/kg feed) and ACV+MS (combination). At the end of the experiment, among the performance criteria tested, body weight, feed intake, egg production and weight of eggs, and feed efficiency were not affected by the treatments (P>0.05). Treatments had no effect on physical external and internal egg characteristics. The amount of yolk malondialdehyde of the ACV and MS groups was lower than the control group (P<0.05) in stored eggs (28 d) (P<0.05).

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  AtıfScopus6·WoS4·OpenAlex7

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