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- MakaleAçık Erişim2021Expression level of the angiotensin 2 (ACE2) gene in patients with COVID-19
Dirican, Ebubekir; Aydin, Ismail Erkan; Savrun, Seyda
Purpose: Coronavirus disease-19 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). The angiotensin converting enzyme 2 (ACE2) can play a vital role in regulating the pathological changes of various diseases, including COVID-19. The aim of this study was to analyze the expression of the ACE2 gene in Turkish COVID-19 patients. Materials and Methods: Eighty COVID-19 PCR test positive patients and 80 PCR test negative healthy volunteers were included in the study. RNA isolation was carried out from all samples. The RT-PCR device was used to analyze the expression of the ACE2 gene. Results: A significant difference was found in the age, Lactate dehydrogenase (LDH), ferritin and C-reactive protein (CRP) levels of the COVID-19 patients compared to the healthy volunteers. Based on the gene expression results, it was found that ACE2 gene expression was significantly higher in COVID-19 patients compared to healthy volunteers. In patients with COVID-19, a significant difference was found between the expression of the ACE2 gene and the levels of Blood urea nitrogen (BUN), Hemoglobin (HGB), Hematocrit (HCT) and CRP. Conclusion: ACE2 gene expression was high in the COVID-19 patients and showed differences based on clinical data. Thus, the expression of ACE2 can have paradoxical effects that support the pathogenicity of SARSCoV2 but, conversely, limit viral infection. The availability of ACE2 receptors may increase the susceptibility and / or disease course of COVID-19.
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İncele - MakaleYalnız künye2021Apitherapy and Muscle Damage
Ceylan, Ramazan; Erdogan, Yasar
Aim: This study aims to compare the effects of dolgit cream, an anti-inflammatory drug in the NSAID group, is frequently used in treating injuries after sports activities, and natural honey, used due to its anti-inflammatory effect, on muscle damage. Methods: Twenty-one amateur male athletes voluntarily participated in this study (Age: 21 +/- 3). The participants were divided into three groups as honey treatment group (n=7), drug treatment group (n=7), and control group (n=7). In the gym, one-session of intense interval training consisting of movements (unusual push-ups, diamond push-ups, dips) in which the athletes participating in the study were not used was applied. Blood samples were taken consecutively for five days, one time before and four times after the training program. Blood samples were analyzed biochemically, and activation of Creatine Kinase (CK), Lactate Dehydrogenase (LDH) enzymes were determined. Besides, the participants' pain levels (Visual Analogue Scale) were monitored for four days after the training. SPSS 22.0 package program was used for data analysis. The suitability of the data for normal distribution was analyzed with the Shapiro-Wilk test, and it was determined that the data were not distributed normally. Kruskal-Wallis test was applied to determine the acute effect of the treatment protocols carried out in the treatment of muscle damage after the training Results: According to the result, no statistically significant difference was found between the treatment groups and the control group in the activation of CK, LDH in the blood serum (p>.05). According to the pain scale follow-up results, it was observed that the pain scores of the participants in the group who received honey treatment were lower and statistically significant in the 1st after the training (p<.05) Conclusion: As a result, the external application of natural honey in sports injuries may support modern medical treatment practices