Sürdürülebilir Kalkınma Amaçları

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Yazarlar

• Belaidi, Salah(1)
• Cinar, Mehmet(1)
• Kerassa, Aicha(1)
• Lanez, Touhami(1)

• MakaleYalnız künye2015Scopus SJRQ2/r/bayburt/12423
  Structure'activity relationships and quantitative structure'activity relationships modeling of some 3-(aryl)-N-(aryl)-1,2,4-Oxadiazol-5-Amine derivatives as anti-proliferative agents

  Belaidi, Salah; Kerassa, Aicha; Lanez, Touhami; Cinar, Mehmet

  Quantitative structure activity relationship studies were performed on a series of 3-(aryl)-N-(aryl)- 1,2,4-oxadiazol-5-amines as anti-proliferative agents, multiple linear regression analysis was performed to derive quantitative structure activity relationship models which were further evaluated internally for the prediction of activity. The developed models were cross-validated by the 'leave one out' technique as well as by the calculation of statistical parameters. The best QSAR model i.e., model-2 (R2 = 0 906, Fischer's test value F = 12066) has acceptable statistical quality and predictive potential as indicated by the value of cross validated squared correlation coefficient (q2 = 0 907). The present investigation indicates the importance of the quantum chemical descriptors, constitutional descriptors and hydrophobicity to study the anti-proliferative activity.

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  AtıfScopus7·WoS4·OpenAlex2

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