Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ2Exome-Wide Association Study of Competitive Performance in Elite Athletes
Bulgay, Celal; Kasakolu, Anil; Kazan, Hasan Hueseyin; Mijaica, Raluca; Zorba, Erdal; Akman, Onur; Bayraktar, Isik; Ekmekci, Ridvan; Koncagul, Seyrani; Ulucan, Korkut
The aim of the study was to identify genetic variants associated with personal best scores in Turkish track and field athletes and to compare allelic frequencies between sprint/power and endurance athletes and controls using a whole-exome sequencing (WES) approach, followed by replication studies in independent cohorts. The discovery phase involved 60 elite Turkish athletes (31 sprint/power and 29 endurance) and 20 ethnically matched controls. The replication phase involved 1132 individuals (115 elite Russian sprinters, 373 elite Russian endurance athletes (of which 75 athletes were with VO2max measurements), 209 controls, 148 Russian and 287 Finnish individuals with muscle fiber composition and cross-sectional area (CSA) data). None of the single nucleotide polymorphisms (SNPs) reached an exome-wide significance level (p < 2.3 x 10(-7)) in genotype-phenotype and case-control studies of Turkish athletes. However, of the 53 nominally (p < 0.05) associated SNPs, four functional variants were replicated. The SIRT1 rs41299232 G allele was significantly over-represented in Turkish (p = 0.047) and Russian (p = 0.018) endurance athletes compared to sprint/power athletes and was associated with increased VO2max (p = 0.037) and a greater proportion of slow-twitch muscle fibers (p = 0.035). The NUP210 rs2280084 A allele was significantly over-represented in Turkish (p = 0.044) and Russian (p = 0.012) endurance athletes compared to sprint/power athletes. The TRPM2 rs1785440 G allele was significantly over-represented in Turkish endurance athletes compared to sprint/power athletes (p = 0.034) and was associated with increased VO2max (p = 0.008). The AGRN rs4074992 C allele was significantly over-represented in Turkish sprint/power athletes compared to endurance athletes (p = 0.037) and was associated with a greater CSA of fast-twitch muscle fibers (p = 0.024). In conclusion, we present the first WES study of athletes showing that this approach can be used to identify novel genetic markers associated with exercise- and sport-related phenotypes.
AtıfScopus20WoS23OpenAlex27
İncele - MakaleAçık Erişim2023Scopus SJRQ2Evaluation of the Association of VDR rs2228570 Polymorphism with Elite Track and Field Athletes' Competitive Performance
Bulgay, Celal; Bayraktar, Isik; Kazan, Hasan Huseyin; Yildirim, Damla Selin; Zorba, Erdal; Akman, Onur; Ergun, Mehmet Ali; Cerit, Mesut; Ulucan, Korkut; Eken, Ozgur
The present study aimed to examine the vitamin D receptor (VDR), rs2228570 polymorphism, and its effect on elite athletes' performance. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 control/ physically inactive, aged 18-35, voluntarily participated in the study. The International Association of Athletics Federations (IAAF) score scale was used to determine the performance levels of the athletes' personal best (PB). Whole exome sequencing (WES) was performed by the genomic DNA isolated from the peripheral blood of the participants. Sports type, sex, and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. The results showed no statistically significant difference between the CC, TC, and TT genotypes within and between the groups (p > 0.05). Additionally, our results underlined that there were no statistically significant differences for the association of rs2228570 polymorphism with PBs within the groups of the (p > 0.05) athletes. The genetic profile in the selected gene was similar in elite endurance, sprint athletes, and in controls, suggesting that rs2228570 polymorphism does not determine competitive performance in the analyzed athlete cohort.
AtıfScopus11WoS10OpenAlex15İncele - MakaleAçık Erişim2022PPARGC1A Gen Polimorfizmi (rs8192678) ile Elit Sporcuların Yarışma Performansları Arasındaki İlişkinin Değerlendirilmesi
Bayraktar, Işık; Zorba, Erdal; Ulucan, Korkut; Bulğay, Celal; Ergun, Mehmet Ali; Kazan, Hasan; Akman, Onur
PPARGC1A (rs8192678) gen polimorfizmi ve atletik performans arasıdaki ilişkiler konusunda sınırlı sayıda araştırma mevcuttur. Bu nedenle, bu çalışmada PPARGC1A genindeki rs8192678 polimorfizminin Türk elit atletizm sporcularının yarışma performansları ile olası ilişkisin araştırılması amaçlamaktadır. Çalışmaya 18-35 yaşları arasında toplam 60 elit sporcu (31 sprint/güç ve 29 dayanıklılık) ve 20 kontrol/sedanter gönüllü olarak katıldı. Atletlerin kişisel en iyi (PB)/yarışma performans düzeylerini belirlemek için Uluslararası Atletizm Federasyonları Birliği (IAAF) puan ölçeği kullanıldı. Tüm ekzom dizilimi (WES), katılımcıların kanından izole edilen genomik DNA tarafından gerçekleştirildi. rs8192678 polimorfizmi ile PB arasındaki ilişki, cinsiyet ve spor deneyimi ayarlaması ile tek yönlü kovaryans analizi (ANCOVA) ile incelendi. Bulgulara göre grup içi ve gruplar arasında, G/G, G/A ve A/A genotip dağılımları arasında anlamlı bir farklılık tespit edilmemiştir (p>0.05). Sonuç olarak, PPARGC1A rs8192678 polimorfizmi ile sporcuların performansı arasında anlamlı hiçbir ilişki tespit edilmemiştir. Ancak, yapılan araştırma hakkında daha net bilgi verebilmek için daha fazla katılımcı ile yapılması önerilir.
AtıfOpenAlex4
İncele