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- MakaleYayıncıda açık erişim2022Scopus SJRQ2Evaluation of photon interaction parameters of Anti-HIV drugs
Akbaba, Uğur; Şakar, Erdem; Abu Al-Sayyed, Mohammed Ibrahim; Alim, Bünyamin; Özpolat, Özgür Fırat
Medical treatment inevitably exposes individuals to radiation, including those taking drugs used to treat and prevent human immunodeficiency virus (HIV). Motivated by this, we investigated the radiation interaction properties of several HIV drugs to determine the interaction parameters, mass attenuation coefficient (MAC), atomic cross section (ACS), electronic cross section (ECS), effective atomic numbers (Zeff), and effective electron density (Neff). We calculated the values using the Phy-X/PSD software in the range of 0.015–15 MeV. Additionally, we calculated the exposure build-up factor (EBF), and energy absorption build-up factor (EABF) values of the drugs up to 40 mean free path (MFP) using the geometric progression (G-P) method. From our findings, we determined that Combivir, with its relatively high heavy element content, had the highest radiation attenuation capacity, whereas the probability of Lopinavir interacting with photons was the lowest compared with the other drugs. The results of the EBF and EABF parameters, including the scattering effects, ordered the drugs opposite to the primary interaction parameters such as MAC, ACS, ECS, and Zeff. These findings can guide the treatment process of HIV-positive patients and inform HIV prevention practices conducted alongside radiotherapy, as the interaction between radiation and a drug may cause deterioration in the drug's structure.
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İncele - MakaleAçık Erişim2021Scopus SJRQ2A surveying of photon and particle radiation interaction characteristics of some perovskite materials
Şakar, Erdem; Alim, Bünyamin; Fırat Özpolat, Özgür; Ceviz Şakar, Betül; Baltakesmez, Ali; Akbaba, Uğur
In this study, we aimed to determinate of the photon and particle radiation interaction parameters of six different perovskites to help use perovskite materials in radiation applications. The parameters that are aimed to be investigated are MAC, HVL, MFP, Zeff, Neff, Ceff and EBF for photons, range values for charged particles, and FNRCS values for neutrons. The photon-interaction parameters the FNRCS values of the perovskites were calculated using Phy-X/PSD software in the energy range of 1 keV–100 GeV for photons and at 4.5 MeV energy for neutrons, respectively. Moreover, the range values of the perovskites were calculated using SRIM Monte Carlo software (for H+ and He++ particles) and ESTAR NIST software (for electrons) in the energy range from 0.01 MeV to 20 MeV. In order to make a notable assessment about the radiation interaction possibilities of the perovskites, the results obtained were compared with some standard shielding materials. According to the results obtained for all radiation types examined, it was determined that all calculated parameters were strongly dependent on both the type and energy of the radiation and the type of material. Additionally, it was observed that the order of preference of the examined materials as armor material in radiation applications varies according to the radiation type and energy. Consequently, it was determined that while the most suitable material in terms of photon shielding is P6 (Cs2SnI6) inorganic perovskite among the perovskites examined, this sample is not suitable material for neutron shielding applications.
AtıfScopus27WoS25OpenAlex26İncele - MakaleYalnız künye2020Scopus SJRQ2Study on the radiation attenuation properties of locally available bees-wax as a tissue equivalent bolus material in radiotherapy
Islam, Sazirul; Mahmoud, K.A.; Sayyed, M.I.; Alim, Bünyamin; Rahman, Md.M.; Mollah, A.S.
In radiation therapy field, bolus material is frequently utilized when treating different areas of a patient, like at the ears or nose, and to provide build-up of dose to the skin surface. The bolus material must be cost effective, suitably flexible to conform to the surface of the patient, and most importantly should be tissue equivalent. The main objective of this work was to estimate the photon attenuation properties of locally available bees-wax and to assess the feasibility of using this bees-wax as a bolus material practice for treatment of cancer patient. The mass attenuation coefficient (μ/ρ) values have been calculated by using MCNP5 simulation code over the wide range of photon energy (0.015–10 MeV). Some related parameters such as the effective atomic number and the mean free path were also calculated to understand the photon attenuation ability of the investigated bolus material. The attenuation properties were also computed for water, tissue and commercial bolus materials for comparison. Evaluation of the results showed that the radiation attenuation properties of locally available bees-wax have a good similarity to water/tissue. Referring to the results of this study, it is proposed that locally available bees-wax is a suitable substance to be used as bolus material practice for treat of cancer patient.
AtıfScopus59WoS53OpenAlex63İncele - MakaleYalnız künye2020Scopus SJRQ2MoO3 reinforced Ultra high molecular weight PE for neutrons shielding applications
Sayyed, M.I.; Abdalsalam, Alyaa H.; Taki, Malaa M.; Mhareb, M.H.A.; Alim, Bünyamin; Baltakesmez, Ali; Şakar, Erdem
Structural, Morphological and neutron attenuation properties of ultrahigh molecular weight polyethylene (UHMWPE) reinforced with molybdenum trioxide composite material obtained by solid state mixing of pellets and powder components via hot pressing have been studied. In this work, Ultra high molecular weight polyethylene and MoO3 has been utilized with different concentration using a hot compression iron mold. The changes in the microstructure of the prepared polymer and its particulate composites were evaluated by SEM. In order to investigate the quantitative of all elements used in these samples, we utilized Energy-dispersive X-ray spectroscopy (EDX) to present the profiles of synthesized samples which show a clear peaks C (carbon), and Mo (Molybdenum). The X-ray diffraction of all samples was examined to study the modification of the phase and lattice for UHMWPE before and after the addition of molybdenum trioxide (MoO3). Raman analysis was utilized to explore the crystallinity, molecular interactions, phase, polymorphy, and chemical structure. This technique is based on non-destructive interaction between light with the chemical bonds inside a material. The Raman spectrum for the current work presented within the range of 150–1600 cm−1. In order to understand the neutron shielding performance for the fabricated UHMWPE with different concentrations of MoO3, 241Am/Be fast neutron source was used to determine the fast neutron radiation equivalent dose rate. The background absorbed dose rate was measured as 0.98 (±0.017) (μSv/h). It was seen that the addition of MoO3 into the UHMWPE enhances the neutron shielding. The dose released from the source was absorbed by 7.71 (±1.3) %, 18.48 (±2.9) %, 22.26 (±2.4) %, 24.07 (±1.8) % and 26.17 (±1.3) % from UHMWPE with 1, 2, 3, 4 and 5% of MoO3 respectively. Additionally, GEANT4 10.02. p01 version was used to calculate total macroscopic cross-sections (TMCS) for the MoO3 doped UHMWPE. According to the results obtained from GEANT4, it was observed that the TMCS values of the UHMWPE increase with increment of the mole fraction of the MoO3 in the structure of UHMWPE examined and that the 5.0% MoO3 sample has the best neutron shielding ability.”
AtıfScopus55WoS54OpenAlex57İncele - MakaleAçık Erişim2019Scopus SJRQ2A study of gamma attenuation property of UHMWPE/Bi 2 O 3 nanocomposites
Abdalsalam, Alyaa H.; Sayyed, M.I.; Ali Hussein, Thulfiqar; Şakar, Erdem; Mhareb, M.H.A.; Ceviz Şakar, Betul; Alim, Bünyamin; Kaky, Kawa M.
In this study, nanocomposite material made of ultra-high molecular weight and bismuth oxide was developed to be used for protection from nuclear radiation. The traditional hot-pressing technique was used for preparing composite samples. The concentrations of Bi 2 O 3 were selected to be 0.5, 1.0, 1.5, 2.0 wt%. In order to study the changes in surface morphology, we examined all samples by scanning electron microscopic (SEM). We evaluated the semi-quantitative of all elements used to fabricate these samples using EDX. Additionally, all samples including pure Bi 2 O 3 has been examined with X-ray diffraction (XRD). Besides that, Raman spectroscopy of all synthesized polymer matrix was measured to explore the different molecular groups. Also, the photon attenuation ability for the present samples was measured experimentally at eight energies varying from 30.8 keV to 383.9 keV using 133 Ba radioactive point source.
AtıfScopus68WoS64OpenAlex70İncele - MakaleAçık Erişim2016Scopus SJRQ2Effect of external magnetic field on valence-electron structures of Fe and Ni in Invar, Permalloy and the other Fe-Ni alloys by using Kβ-to-Kα X-ray intensity ratios
Alim, Bünyamin; Han, Ibrahim; Demir, Lütfü
The effect of external magnetic field on the valence-electron structures of Fe and Ni in various Fe-Ni alloy compositions was investigated by using X-ray fluorescence spectroscopy. Kβ-to-Kα X-rayin-tensity ratios of Fe and Ni in Invar(Fe0.64Ni0.36), Permalloy(Fe0.20Ni0.80) and Fe N - i x 1x Firstly,(x=0, 0.40, 0.52, 0.55, 0.61, and 1) alloys were measured without any magnetic field and under 0.5 and 1 T external magnetic fields, separately. Later, the valence-electron structures of Fe and Ni in both pure form and alloys were obtained by comparison of measured X-ray intensity ratios with the results of multi-configurations Dirac-Fock (MCDF) calculations. The results obtained for valence-electron structures of Fe and Ni in various Fe-Ni alloys were evaluated in terms of magnetic field effect, delocalization and/or charge transfer phenomena. The results have shown that valence electron structure of Fe and Ni in Fe-Ni alloys are dependent on both external magnetic field and concentration of alloy elements.
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