Sürdürülebilir Kalkınma Amaçları

• 2

• MakaleAçık Erişim2023/r/bayburt/14110
  Effect of Reboxetine Treatment on BDNF, Synaptophysin, and PSD-95 Levels in the Spinal Dorsal Horn of Rats with Diabetic Neuropathy

  Yücel, Nazli Turan; Üçel, Umut Irfan; Özkay, Umide Demir; Ulupinar, Emel; Can, Ozgur Devrim

  Objective: It is known that neuropathic pain is accompanied by alterations in the levels of neurotrophic factors and synaptic proteins in the microenvironment of the spinal dorsal horn. Such changes contribute to hyperalgesia and allodynia processes; thus, analgesic drugs can exert their pharmacological effects by affecting the expressions, levels, or functions of these endogenous substances. In this study, based on the knowledge that reboxetine (a selective noradrenaline reuptake inhibitor) has the potential for antihyperalgesic efficacy in diabetic neuropathy, we aimed to examine the probable effects of this drug on diabetes-induced changes in brain-derived neurotrophic factor (BDNF), synaptophysin (the pre-synaptic marker of synaptic integration), and postsynaptic density-95 (PSD-95) (the postsynaptic marker of synaptic integration) levels in the superficial laminae of the dorsal horn.Methods: Experimental diabetes was induced by a single-dose injection of streptozotocin (STZ) (50 mg/kg) in rats. After four week-long induction period of painful diabetic neuropathy, rats were treated orally with 8 mg/kg reboxetine for two weeks. Hyperalgesia responses were evaluated by using the Randall-Selitto and Hargreave's tests. Following the pain tests, immunohistochemical studies were performed.Results: Two weeks of reboxetine administration increased the reduced paw withdrawal thresholds and shortened the paw withdrawal latencies of diabetic rats in neuropathic pain tests, indicating the antihyperalgesic efficacy of this drug. Moreover, augmented BDNF and synaptophysin levels in diabetic rats reversed by reboxetine treatment. However, there was no alteration in the densities of PSD-95, in both STZ-diabetic and reboxetine-treated STZ-diabetic rats.Conclusion: The obtained results suggested that inhibition of central sensitization and modulation of spinal plasticity seem to be pharmacological mechanisms underlying reboxetine's antihyperalgesic effects on diabetic rats. However, further studies are still needed to clarify the exact mechanism of action.

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  AtıfWoS1·OpenAlex1

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• MakaleAçık Erişim2022/r/bayburt/14506
  Exploring Problem Areas of Elderly Patients with Diabetes and the Support Provided by Their Family

  Dastan, Buket; Hintistan, Sevilay

  Objective: Diabetes increases problems in emotional areas particularly among the elderly patients by aggravating negative emotions such as loss, anxiety and fear and makes these patients need higher level of family support. This study aims at exploring problematic areas of the elderly diabetic patients and their family support levels. Methods: The data of this descriptive study were collected by the researcher by conducting a face to face interview with 218 elderly diabetic patients who presented to Endocrine Polyclinics of State Hospital between October 2015 and October 2016. To collect the data, Patient Information Form, Problem Areas in Diabetes Scale (PAID) and Hensarling's Diabetes Family Support Scale (HDFSS) were used. Results: Although problem areas among the patients were found to be fewer than expected; it was found that there were significant differences between problem areas and sex, diabetes time, treatment type, length of oral antidiabetic medicine use and insulin use, development of diabetes-related complication and hospitalization due to these complications in the recent year (p<0.05). Besides, the family support levels of the elderly patients were below the moderate level, and the number of individuals the patients live together with, the number of people receiving support due to diabetes and the number of people who received support from their spouses because of diabetes was a significant variable that affected HDFSS total score and the subscale scores (p<0.05). Conclusion: For a better diabetes management, sex and diabetes related variables should be taken into consideration while delivering health services and increasing family support levels can make positive contributions to the mood of the elderly patients.

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  AtıfWoS1·OpenAlex1

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