Sürdürülebilir Kalkınma Amaçları

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• MakaleYalnız künye2015Scopus SJRQ2/r/bayburt/12423
  Structure'activity relationships and quantitative structure'activity relationships modeling of some 3-(aryl)-N-(aryl)-1,2,4-Oxadiazol-5-Amine derivatives as anti-proliferative agents

  Belaidi, Salah; Kerassa, Aicha; Lanez, Touhami; Cinar, Mehmet

  Quantitative structure activity relationship studies were performed on a series of 3-(aryl)-N-(aryl)- 1,2,4-oxadiazol-5-amines as anti-proliferative agents, multiple linear regression analysis was performed to derive quantitative structure activity relationship models which were further evaluated internally for the prediction of activity. The developed models were cross-validated by the 'leave one out' technique as well as by the calculation of statistical parameters. The best QSAR model i.e., model-2 (R2 = 0 906, Fischer's test value F = 12066) has acceptable statistical quality and predictive potential as indicated by the value of cross validated squared correlation coefficient (q2 = 0 907). The present investigation indicates the importance of the quantum chemical descriptors, constitutional descriptors and hydrophobicity to study the anti-proliferative activity.

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• MakaleAçık Erişim2011Scopus SJRQ2/r/bayburt/14007
  Airy's functions in nonlocal elasticity

  Altan, Burhanettin S.

  Nanostructured devices and materials, such as carbon nanotubes, Atomic Force Microscope, MEMS, etc. attract increasing attention in the scientific world. It has been realized that the classical elasticity is not capable to capture the mechanical behavior of them precisely. There is a wide consensus among the scientists that nonlocal elasticity is more capable than the classical counterpart to model the mechanical behavior of nanostructured materials and devices. In this paper a method which is useful for solving problems in nonlocal is introduced. Airy's stress functions for plane stress problems in nonlocal elasticity are studied. The nonlocal constitutive equations in integral form are discussed and a method is suggested to invert the constitutive equation which allows expressing strains in terms of stresses. A qualitative discussion is given on this inversion process. For the nonlocality kernel of exponential form, the differential equation for Airy's functions in nonlocal elasticity is obtained by introducing the strains into the compatibility condition. Appropriate polynomial forms for the Airy's function are considered and are applied to solve beam bending problems. The solutions are compared with their classical counterparts. The results are given in a series of figures and tables and are discussed in detail. This paper is concluded by indicating the implications of the presented study in nanomechanics and nanotechnology.

  AtıfScopus1·OpenAlex1

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