Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2026Scopus SJRQ2/r/bayburt/10789
  Comprehensive characterization of 26 Turkish asteraceae species: Insights from FTIR, phytochemical composition, and elemental analysis via ICP-MS

  Civas, Ayse; Karakas, Seydanur; Bayrak, Burak; Akyüz, Beyzanur; Keçeci, Emire Bengisu; Özerd, Elif Beyza; Sönmez, Hatice Rumeysa; Asgarli, Tugay; Disli, Fatma Taeb; Yuca, Hafize

  This study provides a comprehensive phytochemical, elemental, and spectroscopic characterization of 26 species belonging to the Asteraceae family, several of which are endemic to T & uuml;rkiye and traditionally used in folk medicine. Qualitative screening revealed the widespread presence of flavonoids, saponins, tannins, and carbohydrates, while alkaloids and anthracene heterosides were entirely absent in all taxa. Among the species analyzed, Cichorium intybus, Cyanus depressus, Achillea arabica, and Cirsium davisianum exhibited the richest phytochemical diversity, suggesting strong biological potential. Quantitative evaluation showed that Klasea serratuloides possessed the highest total phenolic content (99.49 mu g GAE/mg extract), followed by Artemisia scoparia and Inula sarana, indicating notable antioxidant potential. Elemental analysis by ICP-MS demonstrated significant interspecies variation, with Centaurea armena, Centaurea arvensis, and Cichorium intybus containing elevated levels of essential macro- and trace elements such as K, Mg, Ca, Zn, and Se, whereas Helichrysum plicatum and Scorzonera ulrichii showed high Co and Se contents. Conversely, trace levels of potentially toxic elements (e.g., Al, U) were detected in some taxa, emphasizing the need for careful evaluation of their pharmacological use. FTIR analysis confirmed the presence of functional groups characteristic of phenolics, flavonoids, tannins, coumarins, and cardioactive heterosides, as indicated by distinct O-H (3200-3600 cm-1), C-H (2850-2950 cm-1), and C=O (1700-1650 cm-1) stretching bands. The combined interpretation of phytochemical and FTIR data underscores the chemical diversity and functional group complexity of these plant extracts. Overall, the results highlight the nutritional and pharmacognostic significance of several Asteraceae species, supporting their potential application in antioxidant, nutraceutical, and therapeutic formulations.

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• MakaleYayıncıda açık erişim2026Scopus SJRQ2/r/bayburt/12779
  Dual antidepressant-like and antinociceptive effects of Hypericum olympicum extract in mice: preclinical behavioral evidence

  Saltan, Nagehan; Üçel, Umut İrfan; Göger, Fatih; Özkay, Ümide Demir; Can, Özgür Devrim

  Hypericum Tourn. ex L. species exhibit well-documented neuropsychopharmacological activities, yet the central effects of Hypericum olympicum L. remain unknown. Given the frequent comorbidity of depressive symptoms and pain, this study aimed to characterize, for the first time, the antidepressant-like and antinociceptive profile of H. olympicum in mice. A methanolic extract of the aerial parts (HoE) was prepared, and its major phenolic constituents were identified by LC-MS/MS. At behaviorally active doses, HoE (2.5 and 5 mg/kg, i.p.) did not impair motor coordination in the Rota-rod test, in contrast to diazepam (2 mg/kg, p.o.), indicating the absence of neuromotor confounding effects. In both the tail suspension test (TST) and the modified forced swim test (MFST), HoE significantly reduced immobility, with effects comparable to those of fluoxetine (30 mg/kg, p.o.). In the MFST, increased swimming behavior without changes in climbing suggested a predominantly serotonergic component. HoE also produced marked antinociceptive effects in multiple nociceptive models. It increased response latencies in the hot-plate, tail-immersion, and tail-clip tests, reflecting activity in supraspinal and spinal thermal and mechanical nociceptive processing. In addition, HoE significantly reduced acetic acid-induced writhing, indicating visceral antinociceptive activity. Morphine (10 mg/kg, i.p.) served as the positive control in pain assays. LC-MS/MS analysis indicated the presence of major phenolic constituents, including hyperoside, myricetin derivatives, caffeoylquinic acid derivatives, a luteolin/kaempferol-type glucoside, and a biflavone of the biapigenin/amentoflavone type. These findings suggest that HoE possesses dual antidepressant-like and antinociceptive properties and support its further evaluation for disorders at the affect–pain interface.

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• MakaleAçık Erişim2024Scopus SJRQ2/r/bayburt/12908
  Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats

  Sevinç Gül, Sema Nur; Özkal Eminoğlu, Didem; Tekçe, Emre; Bayraktar, Bülent; Güven, Leyla; Dilsiz, Alparslan; Yıldırım, Serkan; Sait, Ahmet

  A chronic microbial infection that is mediated by the host's immune system is the cause of periodontal disease. As the world's population grows, phytotherapy is a therapeutic strategy that makes use of a renewable resource that can provide less costly medicines. This study aimed to investigate the therapeutic effects of eugenol administration on periodontitis by examining the effects of eugenol at different doses biochemically, histopathologically, and radiologically in rats with experimental periodontitis. Thirty-two Sprague Dawley male rats were divided into four groups: 1. the healthy control group (CG), 2. The experimental periodontitis group (PG), 3. The experimental periodontitis+10 mg/kg eugenol group (EG10), and 4. the experimental periodontitis+20 mg/kg eugenol group (EG20). Alveolar bone loss was measured using micro-CT imaging. The TNF-α, IL-6, leptin, asprosin, and apelin levels were analyzed in the serum samples of rats. Histological and immunohistochemical analyses were performed. The data were analyzed statistically. The serum TNF-α, IL-6, leptin, asprosin, and apelin levels were found to be statistically significantly lower in the eugenol-applied groups (EG10 and EG20) than in the PG (p < 0.05). There was a statistically significant difference in the TNF-α, IL-6, leptin, asprosin, and apelin levels between the EG10 and EG20 (p < 0.05). In the measurements made using micro-CT imaging, alveolar bone loss was found to be at the lowest FR1 level, and in histopathological analysis, the least inflammation was observed in the EG20. It was concluded that the application of 20 mg/kg eugenol in rats with experimental periodontitis was a safe dose, was beneficial in alleviating bone loss, and had a positive effect on the healing process.

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  AtıfScopus2·WoS2·OpenAlex2

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• MakaleAçık Erişim2022Scopus SJRQ2/r/bayburt/13287
  Anatomy, trichome micromorphology and phytochemical profile of Stachys rizeensis R.Bhattacharjee from Turkey

  Gerçek, Yusuf Can; Acar Şahin, Aydan; Ecem Bayram, Nesrin; Çelik, Saffet; Sefalı, Abdurrahman; Gıdık, Betül; Cevahir Öz, Gül; Pınar, Nur Münevver

  In recent years, the popularity of natural products and natural product formulations has increased due to their beneficial effects on health. As a part of this trend, Lamiaceae family members have attracted attention due to their rich bioactive properties. Although the Stachys rizeensis R.Bhattacharjee plant is an endemic plant species in Turkey, no studies focus on its characterization. Hence, the present study aims to demonstrate the anatomical, morphological and phytochemical characterization of S. rizeensis in Turkey. In the first stage of the study, anatomical and trichome morphological characterization was performed to contribute to the taxonomic definition of S. rizeensis was found to be anatomically different from some other previously studied Stachys sp. by showing lacunar collenchyma type, uncertain cambium at the corners, two or three rows of endodermis in certain areas in the stem and two rows of palisade parenchyma, capitate and peltate glandular trichomes in the leaf. In the second stage, the phenolic profile, total phenolic/flavonoid content and antioxidant activity of the plant extracts prepared using solvents with different polarities (ethanol, methanol, water, ethyl acetate and hexane) were tested to determine the phytochemical content of the plant. The phytochemical analysis supported by chemometric analysis (PCA and HCA) revealed that methanol was the most efficient organic solvent for the extraction of the phytochemical compounds of the plant. Additionally, it was observed that chlorogenic acid (1842.40–217,086.19 mg/kg), verbascoside (2591.43–204,429.81 mg/kg), luteolin (3579.56–88,636.14 mg/kg) and kaempferol (9706.30–50,340.93 mg/kg) compounds were present at maximum levels in this plant, in which 31 different phenolic compounds were scanned using LC-MS/MS. In addition, results obtained from the phytochemical analysis revealed that S. rizeensis is a valuable plant that can be used for medical protection/treatment and that it could also have a variety of culinary applications. The present study served as the first original report regarding the chemical profile and anatomical characteristics of S. rizeensis (Lamiaceae) from Turkey.

  AtıfScopus4·WoS4·OpenAlex4

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