Yazarlar

• Kiliç, Hamdullah(1)
• Çakici, Murat(1)
• Özdemir, Halide Sedef(1)
• Şahin, Engin(1)

• MakaleAçık Erişim2015Scopus SJRQ1/r/bayburt/12338
  Asymmetric Friedel-Crafts alkylation of pyrrole with nitroalkenes catalyzed by a copper complex of a bisphenol A-derived Schiff base

  Özdemir, Halide Sedef; Şahin, Engin; Çakici, Murat; Kiliç, Hamdullah

  The asymmetric Friedel-Crafts (FC) alkylation of pyrrole with nitroalkenes was mediated by CuBr2 and a novel bisphenol A-derived chiral catalyst at room temperature. The catalyst was found to be applicable for the asymmetric FC alkylation of pyrrole with a wide range of nitroalkenes, affording optically active alkylated pyrroles with enantioselectivities up to 94%. Furthermore, enantiomerically pure 3-nitro-2-arylpropanamides were prepared by the oxidative cleavage of the pyrrole rings in the FC products with NaIO4/RuCl3 to demonstrate the synthetic application of the products.

  AtıfScopus18·WoS15·OpenAlex17

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