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- MakaleYalnız künye2023Scopus SJRQ2Design, synthesis, antioxidant and anticholinesterase activities of novel isonicotinic hydrazide-hydrazone derivatives
Aslanhan, Özlem; Kalay, Erbay; Tokalı, Feyzi Sinan; Can, Zehra; Şahin, Engin
The design and synthesis of hydrazone derivatives are increasing in popularity day by day due to the significant biological activities of this scaffold. In the present study, twelve novel isonicotinic hydrazide-hydrazone analogues were synthesized by the condensation reaction of isonicotinic hydrazide with benzaldehyde possessing sulfonate moiety. The structures of the novel compounds have been characterized in detail using spectroscopic techniques. All compounds have shown inhibitory effects against the AChE enzyme at rates ranging from 21.00 to 59.48%. Among them, compound 5 has exhibited the best inhibitory effect of 59.48% against AChE at a concentration of 0.1 mM. Furthermore, to determine how effective the novel compounds are as antioxidants, FRAP and DPPH studies were also carried out. FRAP values in compounds 1–12 were found to range from 26.989–3415.556 µmol FeSO4.7H2O/mg. They also displayed moderate antioxidant potential in the range of SC50=0.03–87.32 mg/mL compared with the control Trolox (SC50 =0.004) in DPPH radical scavenging activities. It was seen that the AChE inhibition percentages of the compounds were in the range of 23.04–58.10% at 0.1 mM concentration. This is the first research on the synthesis, antioxidant and enzyme inhibition properties of these compounds.
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İncele - MakaleYalnız künye2019Scopus SJRQ4Some edible forest fruits their in vitro antioxidant activities, phenolic compounds and some enzyme inhibition effects
Okan, Onur Tolga; Serencanr, Huseyin; Baltas, Niniet; Can, Zehra
The purpose of the study was to analyze the po-tential health-pro mo ting components of some edible forest species of fruits. These are Service tree (Sor-bus domestica), Black rosehip (Rosa pimpinelli-folia), Red rosehip (Rosa carina), Bay fruit {Lawns nobilis), Cornelian cherry (Cornus mas), Autumn-olive (Elaeagrtus umbellate), and two different blue-berry fruits (Vaccinium arctostaplylos and Vaccin-ium myrtillus). In the present study, chemical and an-tioxidant activities, phenolic compounds as well as, inhibition effects on important enzymes (acetylcho-linesterase, xanthine oxidase and urease) of fruits were studied. Total polyphenol, flavonoid content, and the in-vitro antioxidant activity were evaluated by DPPH and FRAP. The sugar contents and phe-nolic compounds of the fruits were analyzed by HPLC-RJD and HPLC-UV. Fruits was determined the total polyphenol content (TPC) 1.10 to 19.87 mgGAE/g, total flavonoid content (TFC) 0.01 to 0.80 mgQE/g, DPPH values 0.22 to 6.03 mg/mL and FRAP values 4.24 to 168. 02 umol FeSO47H2O/g. All samples were determined various rate fructose and glucose. HPLC-UV revealed fruits contained different phenolic compounds. Inhibition values of the enzymes were expressed as inhibition concentra-tion (IC50: Mg/mL or ug/mL). It can be concluded that edible forest fruits are a potential source of anti-oxidants with therapeutic importance as well a natu-ral enzyme inhibitor.
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