Yazarlar
Yayınlar
- MakaleAçık Erişim2017Scopus SJRQ2Some approaches to multi criteria decision making based on exponential operations of simplified neutrosophic numbers
Şahin, Rdvan; Liu, Peide
Simplified neutrosophic set (SNS) is a powerful tool that attracts the attention of many scholars in dealing with uncertainty and vagueness. A SNS is based on a combination of simplified neutrosophic numbers (SNNs), whose its basic components are characterized by a truth-membership degree, an indeterminacy-membership degree and a falsity-membership degree of an object in evaluation data. Aggregation operators used to synthesize simplified neutrosophic information is commonly not very effective in case where the criteria weights provided by decision makers are in form of SNNs rather than exact real numbers. In this paper, we propose two new operational laws in which the bases are positive real numbers and interval numbers, respectively and the exponents are SNNs, and discuss some of their desired properties. Then we apply them to derive two weighted exponential aggregation operators, such as the simplified neutrosophic weighted exponential aggregation (SNWEA) operator and dual simplified neutrosophic weighted exponential aggregation (DSNWEA) operator. Additionally, two approaches for multi-criteria decision-making (MCDM) problems under the neutrosophic weight data are explored by applying these aggregation operators. At the end of the study, a convenient example is provided to demonstrate the availability and effectiveness of the proposed methods.
AtıfScopus18WoS17OpenAlex17
İncele - MakaleAçık Erişim2016Scopus SJRQ3Correlation between the DNA methylation and gene expression of IGFBP5 in breast cancer
Karabulut, Sevgi; Kaya, Zehra; Amuran, Gökçe Gullu; Peker, Irem; Özmen, Tolga; Gulluolu, Bahadir M.; Kaya, Handan; Erzik, Can; Ozer, Ayşe; Akkiprik, Mustafa
BACKGROUND: The insulin-like growth factor binding protein5 (IGFBP5) is often dysregulated in human cancers and considered neither a tumor suppressor nor an oncogene. OBJECTIVE: We aim to examine the reason of the changeable gene regulation of IGFBP5 in the case of methylation in breast cancer. METHODS: We used methyl-specific polymerase (MSP) chain reaction to detect CpG methylation of IGFBP5 promoter and exon-I in breast cancer and adjacent tissues. Gene expression is evaluated by quantative polymerase chain reaction (qPCR). RESULTS: IGFBP5 methylation was detected in 24 of 58 (41%) and 54 of 56 (96.5%) promoter and exon-I site respectively in tumor tissues. In adjacent tissues 17 of 58 (29%) and 53 of 56 (96.5%) was methylated. IGFBP5 expression was higher estrogene receptor (ER)(+) than ER(-) patients (p = 0:0549). Beside, we found a positive correlation between the expression of IGFBP5 and G2 tumor grade (p = 0:0131). However, no correlation was observed between IGFBP5 expression and age, menopause or the presence of lymph node metastasis (p > 0:05). CONCLUSIONS: In summary, our results showed that IGFBP5 promoter and exon-I methylation did not have any differences between tumor and adjacent tissues so that IGFBP5 methylation did not change IGFBP5 gene regulation in breast cancer. This is the first study investigating the IGFBP5 gene methylation in breast cancer.
AtıfScopus9
İncele - MakaleAçık Erişim2015Scopus SJRQ4Synthesis, characterization and complexation properties of a novel Mg-porphyrazine with metal ions in acetonitrile-chloroform
Kabay, Nilgün; Baygu, Yasemin; Gök, Yaşar; Başoʇlu, Aysel; Ocak, Ümmühan
The synthesis and characterization of a novel metal derivative of a peripherally symmetrically tetra-substituted porphyrazine derived from 25,26-dioxa-6,7,9,10,15,16,18,19-octahydro-25H-1,24-methanodibenzo[q,t][1,4,13,16,17,10]tetraoxadithiacyclohenicosine-12,13-dicarbonitrile was carried out. The influence of metal cations such as Zn2+, Fe2+, Mn2+, Ni2+, Co2+, Hg2+ and Cu2+ on the spectroscopic properties of the ligands, the starting material dinitrile and MgPz were investigated in acetonitrile-chloroform solution (1/1) by means of absorption spectrometry. Absorption spectra showed isosbestic points in the spectrophotometric titration of Cu2+ and Hg2+ with MgPz ligand. The results of spectrophotometric titration experiments disclosed the complex stability constant of the novel ligand, MgPz with Cu2+ and Hg2+ cations.
- DergiBreast Disease
- DergiJournal of Intelligent and Fuzzy Systems