2026-10-30T03:59:47Zhttps://bayburt-rdlopen.rawdatalibrary.net/oai/requestoai:bayburt-rdlopen.rawdatalibrary.net:bayburt/137952026-10-29T19:52:18Zopenairedrivercom_bayburt_10000col_bayburt_10001com_bayburt_10007col_bayburt_10218Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: An in vitro studySöyüt, HakanKaya, Elif DuyguBeydemir, ŞükrüCefoperazone sodiumInhibitionMeropenem trihydrateParaoxonasePiperacillin sodiumObjective: To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase (hPON1). Methods: hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography. Results: The three antibacterial drugs decreased in vitro hPON1 activity. Inhibition mechanisms meropenem trihydrate was noncompetitive while piperacillin sodium and cefoperazone sodium were competitive. Conclusions: Our results showed that antibacterial drugs significantly inhibit hPON1 activity, both in vitro, with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro.Asian Pacific Tropical Biomedicine Press2014Articlehttps://rdlopen.rawdatalibrary.net/r/bayburt/13795https://doi.org/10.12980/apjtb.4.2014apjtb-2014-00592221-1691enAsian Pacific Journal of Tropical Biomedicineinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://bayburt-rdlopen.rawdatalibrary.net/tr/items/bayburt/13795