2026-10-30T02:12:01Zhttps://bayburt-rdlopen.rawdatalibrary.net/oai/request

oai:bayburt-rdlopen.rawdatalibrary.net:bayburt/133392026-10-29T19:52:13Zopenairecom_bayburt_10000col_bayburt_10001com_bayburt_10007col_bayburt_10225

Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, α-glucosidase inhibition properties and docking studyIzgi, SametSengul, Ibrahim F.Şahin, EnginKoca, Mehmet SerdarCebeci, FatmaKandemir, Hakan1,3,4-oxadiazole7-azaindoleAntioxidant activityDocking studyα-glucosidase inhibitionIn this current work, 7-azaindole based 1,3,4-oxadiazoles have been successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the corresponding carbohydrazides, followed by iodine mediated synthetic protocol in order to afford the corresponding 2,5-disubstituted 1,3,4-oxadiazoles. The full characterization data of the novel compounds were obtained by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry and single crystal X-ray diffraction techniques. The antioxidant activity and α-glucosidase inhibition potential of the prepared compounds are examined by in vitro assays. The targeted hydrazide linked 7-azaindoles and their corresponding cyclized form 1,3,4-oxadiazoles exhibited inhibitory potential with IC50 values ranges between 0.46 and 24.92 mM. Plausible binding mode and interaction of ligands with α-glucosidase enzyme have been studied by molecular docking, supporting the experimental results.Elsevier B.V.2022Articlehttps://rdlopen.rawdatalibrary.net/r/bayburt/13339https://doi.org/10.1016/j.molstruc.2021.1313430022-2860enJournal of Molecular Structureinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://bayburt-rdlopen.rawdatalibrary.net/tr/items/bayburt/13339