2026-10-30T05:18:58Zhttps://bayburt-rdlopen.rawdatalibrary.net/oai/requestoai:bayburt-rdlopen.rawdatalibrary.net:bayburt/122472026-10-29T19:42:18Zopenairedrivercom_bayburt_10000col_bayburt_10001com_bayburt_10010col_bayburt_10222The anti-genotoxic effect of some lichenic acidsKizil, Hamit EmreCeker, SelcukCapik, OzelAgar, GulerayAntigenotoxic activityComet assayDiffractaic acidLecanoric acidLichen compoundsLobaric acidVulpinic acidFour lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 μgmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 μgmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid.National Science Foundation2018Articlehttps://rdlopen.rawdatalibrary.net/r/bayburt/12247https://doi.org/10.4038/jnsfsr.v46i2.84231391-4588enJournal of the National Science Foundation of Sri Lankainfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://bayburt-rdlopen.rawdatalibrary.net/tr/items/bayburt/12247