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oai:bayburt-rdlopen.rawdatalibrary.net:bayburt/118352026-10-29T19:41:59Zopenairecom_bayburt_10000col_bayburt_10001com_bayburt_10010col_bayburt_10222com_bayburt_10007col_bayburt_10225

Methoxy-activated indole-7-carbohydrazides; synthesis, antioxidant, and anticancer propertiesKandemir, Hakanİzgi, SametCınar, IrfanCebeci, FatmaDirican, EbubekirSaglam, Mehmet F.Sengul, Ibrahim F.Indole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully synthesized starting from the readily available 3-phenyl and 2,3-diphenyl 4,6-dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry, and single crystal X- ray diffraction techniques. In addition, the indole-7-carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH-SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA-MB-231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells.HeteroCorporation2023Articlehttps://rdlopen.rawdatalibrary.net/r/bayburt/11835https://doi.org/10.1002/jhet.45620022-152XenJournal of Heterocyclic Chemistryinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://bayburt-rdlopen.rawdatalibrary.net/tr/items/bayburt/11835